update on microbial carotenoid production: application of recent metabolic engineering tools

Carotenoids are ubiquitous pigments synthesized by plants, fungi, algae, and bacteria. Industrially, carotenoids are used in pharmaceuticals, neutraceuticals, and animal feed additives, as well as colorants in cosmetics and foods. Scientific interest in dietary carotenoids has increased in recent ye...

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Bibliographic Details
Published in:Applied microbiology and biotechnology 2007-12, Vol.77 (3), p.505-512
Main Authors: Das, Amitabha, Yoon, Sang-Hwal, Lee, Sook-Hee, Kim, Jae-Yean, Oh, Deok-Kun, Kim, Seon-Won
Format: Article
Language:English
Subjects:
Algae
Bacteria - genetics
Bacteria - metabolism
Bioengineering
Biological and medical sciences
Biosynthesis
Biotechnology
Carotenoids
Carotenoids - genetics
Carotenoids - metabolism
Cosmetics
E coli
Engineering
Enzymes
Escherichia coli
Escherichia coli - genetics
Escherichia coli - metabolism
Feed additives
Fermentation
Functional foods & nutraceuticals
Fundamental and applied biological sciences. Psychology
Genetic Engineering
Health risks
Hemiterpenes - metabolism
Immune system
Isopentenyl diphosphate
MEP
Metabolic engineering
Metabolism
Metabolites
Mevalonate
Microbiology
Microorganisms
Organophosphorus Compounds - metabolism
Prenyl diphosphate
Studies
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Summary:Carotenoids are ubiquitous pigments synthesized by plants, fungi, algae, and bacteria. Industrially, carotenoids are used in pharmaceuticals, neutraceuticals, and animal feed additives, as well as colorants in cosmetics and foods. Scientific interest in dietary carotenoids has increased in recent years because of their beneficial effects on human health, such as lowering the risk of cancer and enhancement of immune system function, which are attributed to their antioxidant potential. The availability of carotenoid genes from carotenogenic microbes has made possible the synthesis of carotenoids in non-carotenogenic microbes. The increasing interest in microbial sources of carotenoid is related to consumer preferences for natural additives and the potential cost effectiveness of creating carotenoids via microbial biotechnology. In this review, we will describe the recent progress made in metabolic engineering of non-carotenogenic microorganisms with particular focus on the potential of Escherichia coli for improved carotenoid productivity.
ISSN:0175-7598
1432-0614
DOI:10.1007/s00253-007-1206-3