Different Effects of SLCO1B1 Polymorphism on the Pharmacokinetics of Atorvastatin and Rosuvastatin

Thirty‐two healthy volunteers with different SLCO1B1 genotypes ingested a 20 mg dose of atorvastatin and 10 mg dose of rosuvastatin with a washout period of 1 week. Subjects with the SLCO1B1 c.521CC genotype (n=4) had a 144% (P

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2007-12, Vol.82 (6), p.726-733
Main Authors: Pasanen, M K, Fredrikson, H, Neuvonen, P J, Niemi, M
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Area Under Curve
Atorvastatin Calcium
European Continental Ancestry Group - genetics
Female
Fluorobenzenes - administration & dosage
Fluorobenzenes - blood
Fluorobenzenes - pharmacokinetics
Genotype
Heptanoic Acids - administration & dosage
Heptanoic Acids - blood
Heptanoic Acids - pharmacokinetics
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics
Liver - metabolism
Male
Organic Anion Transporters - genetics
Organic Anion Transporters - metabolism
Polymorphism, Genetic
Prospective Studies
Pyrimidines - administration & dosage
Pyrimidines - blood
Pyrimidines - pharmacokinetics
Pyrroles - administration & dosage
Pyrroles - blood
Pyrroles - pharmacokinetics
Reference Values
Rosuvastatin Calcium
Solute Carrier Organic Anion Transporter Family Member 1b1
Sulfonamides - administration & dosage
Sulfonamides - blood
Sulfonamides - pharmacokinetics
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Description
Summary:Thirty‐two healthy volunteers with different SLCO1B1 genotypes ingested a 20 mg dose of atorvastatin and 10 mg dose of rosuvastatin with a washout period of 1 week. Subjects with the SLCO1B1 c.521CC genotype (n=4) had a 144% (P
ISSN:0009-9236
1532-6535
DOI:10.1038/sj.clpt.6100220