Post-chemiluminescence Phenomenon of NBS-Luminol Reactions and Their Applications to Flow Injection Analysis of Piroxicam

A new post-chemiluminescence (PCL) reaction was observed when piroxicam was injected into the reaction mixture after the CL reaction of N-bromosuccinimide (NBS) and luminol. A possible reaction mechanism was proposed based on the studies of the CL kinetic characteristics, the CL spectra, fluorescenc...

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Bibliographic Details
Published in:Analytical Sciences 2007, Vol.23(11), pp.1301-1304
Main Authors: BAI, Hao, NIE, Fei, LU, Jiuru
Format: Article
Language:English
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Summary:A new post-chemiluminescence (PCL) reaction was observed when piroxicam was injected into the reaction mixture after the CL reaction of N-bromosuccinimide (NBS) and luminol. A possible reaction mechanism was proposed based on the studies of the CL kinetic characteristics, the CL spectra, fluorescence spectra and other experiments. A new flow injection CL method for the determination of piroxicam was established based on the PCL reaction. The relative standard deviation (RSD) for the determination of piroxicam was 1.2% (n = 11, c = 2.0 × 10-6 g/ml). The CL intensity responded linearly to the concentration of piroxicam in the range 1.0 × 10-7 - 1.0 × 10-5 g/ml (r = 0.9991). The detection limit was 4.0 × 10-8 g/ml. The method had been applied to the determination of piroxicam in tablets with satisfactory results.
ISSN:0910-6340
1348-2246
DOI:10.2116/analsci.23.1301