Metabolic profiling of arginine and nitric oxide pathways predicts hemodynamic abnormalities and mortality in patients with cardiogenic shock after acute myocardial infarction

It is unclear whether abnormalities of arginine and nitric oxide metabolism are related to hemodynamic dysfunction and mortality in patients with cardiogenic shock (CS) after acute myocardial infarction. Plasma metabolites reflecting arginine bioavailability, nitric oxide metabolism, and protein oxi...

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Published in:Circulation (New York, N.Y.) N.Y.), 2007-11, Vol.116 (20), p.2315-2324
Main Authors: NICHOLLS, Stephen J, ZENENG WANG, HOCHMAN, Judith S, HAZEN, Stanley L, KOETH, Robert, LEVISON, Bruce, DELFRAINO, Brian, DZAVIK, Vladimir, GRIFFITH, Owen W, HATHAWAY, David, PANZA, Julio A, NISSEN, Steven E
Format: Article
Language:English
Subjects:
Aged
Arginine - metabolism
Biological and medical sciences
Biomarkers
Blood and lymphatic vessels
Cardiology. Vascular system
Citrulline - metabolism
Coronary heart disease
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Heart
Humans
Male
Medical sciences
Methylation
Myocardial Infarction - metabolism
Myocardial Infarction - mortality
Neurology
Nitric Oxide - metabolism
Ornithine - metabolism
Oxidation-Reduction
Oxidative Stress
Predictive Value of Tests
Shock, Cardiogenic - metabolism
Shock, Cardiogenic - mortality
Vascular diseases and vascular malformations of the nervous system
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Summary:It is unclear whether abnormalities of arginine and nitric oxide metabolism are related to hemodynamic dysfunction and mortality in patients with cardiogenic shock (CS) after acute myocardial infarction. Plasma metabolites reflecting arginine bioavailability, nitric oxide metabolism, and protein oxidation were analyzed by mass spectrometry in patients with CS (n=79) and age- and gender-matched patients with coronary artery disease and normal left ventricular function (n=79). CS patients had higher levels of asymmetric dimethylarginine (ADMA; P
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.107.693986