Protective effect of Toki-shakuyaku-san on amyloid beta25-35-induced neuronal damage in cultured rat cortical neurons

Amyloid beta protein (Abeta) is the major component of senile plaques, the pathological hallmark of the neurodegeneration associated with Alzheimer's disease (AD). This study investigated the effect of Toki-shakuyaku-san (TSS), a traditional medicine, on Abeta25-35-induced neuronal death and li...

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Published in:Phytotherapy research 2005-05, Vol.19 (5), p.450-453
Main Authors: Egashira, Nobuaki, Iwasaki, Katsunori, Akiyoshi, Yuki, Takagaki, Yuki, Hatip-Al-Khatib, Izzettin, Mishima, Kenichi, Kurauchi, Kouji, Ikeda, Tomoaki, Fujiwara, Michihiro
Format: Article
Language:English
Subjects:
Amyloid beta-Peptides
Animals
Apoptosis - drug effects
Cerebral Cortex - cytology
Cerebral Cortex - drug effects
Dose-Response Relationship, Drug
Drugs, Chinese Herbal
L-Lactate Dehydrogenase - metabolism
Lipid Peroxidation - drug effects
Malondialdehyde - metabolism
Neurons - cytology
Neurons - drug effects
Neuroprotective Agents - administration & dosage
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Peptide Fragments
Phytotherapy
Rats
Rats, Wistar
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Summary:Amyloid beta protein (Abeta) is the major component of senile plaques, the pathological hallmark of the neurodegeneration associated with Alzheimer's disease (AD). This study investigated the effect of Toki-shakuyaku-san (TSS), a traditional medicine, on Abeta25-35-induced neuronal death and lipid peroxidation assessed by measuring lactate dehydrogenase (LDH) and malondialdehyde (MDA), respectively. Abeta25-35 at 10 microM induced neuronal damage and increased the LDH and MDA. TSS at concentrations of 100 and 300 microg/mL significantly reduced the Abeta25-35-induced neuronal death and the lipid peroxidation. These results suggest that TSS has a protective effect against Abeta25-35-induced neuronal damage. TSS may be beneficial for the treatment of AD.
ISSN:0951-418X