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Laminar Specificity of Intrinsic Connections in Broca's Area

Broca's area and its right hemisphere homologue comprise 2 cytoarchitectonic subdivisions, FDΓ and FCBm of von Economo C and Koskinas GN (1925, Die Cytoarchitektonik der Hirnrinde des erwachsenen Menschen. Vienna/Berlin [Germany]: Springer). We report here on intrinsic connections within these...

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Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2007-12, Vol.17 (12), p.2949-2960
Main Authors: Tardif, Eric, Probst, Alphonse, Clarke, Stephanie
Format: Article
Language:English
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Summary:Broca's area and its right hemisphere homologue comprise 2 cytoarchitectonic subdivisions, FDΓ and FCBm of von Economo C and Koskinas GN (1925, Die Cytoarchitektonik der Hirnrinde des erwachsenen Menschen. Vienna/Berlin [Germany]: Springer). We report here on intrinsic connections within these areas, as revealed with biotinylated dextran amine and 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate tracing in postmortem human brains. Injections limited to supragranular layers revealed a complex intrinsic network of horizontal connections within layers II and III spreading over several millimeters and to a lesser extent within layers IV, V, and VI. Ninety percent of the retrogradely labeled neurons (n = 734) were in supragranular layers, 4% in layer IV, and 6% in infragranular layers; most were pyramids and tended to be grouped into clusters of approximately 500 μm in diameter. Injections involving layer IV revealed extended horizontal connections within layers I–IV (up to 3.7 mm) and to a lesser extent in layers V and VI. Injections limited to the infragranular layers revealed horizontal connections mainly limited to these layers. Thus, intrinsic connections within Broca's area display a strong laminar specificity. This pattern is very similar in areas FDΓ and FCBm and in the 2 hemispheres.
ISSN:1047-3211
1460-2199
DOI:10.1093/cercor/bhm021