Intracranial Pressure Observations in a Canine Model of Acute Liver Failure Supported by a Bioartificial Liver Support System

:  Life‐threatening, severely elevated intracranial pressure (ICP) is a common feature of acute liver failure (ALF). Perfusion with a bioartificial liver may serve to mitigate rising ICP. A retrospective analysis of ICP measurements in a canine ALF model prospectively supported with a bioartificial...

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Bibliographic Details
Published in:Artificial organs 2007-11, Vol.31 (11), p.834-839
Main Authors: Patzer II, John F., Lopez, Roberto C., Aggarwal, Shushma
Format: Article
Language:English
Subjects:
Acute liver failure
Animals
Bioartificial liver
Disease Models, Animal
Dogs
Galactosamine
Intracranial Hypertension - etiology
Intracranial Hypertension - prevention & control
Intracranial Pressure
Liver Failure, Acute - complications
Liver Failure, Acute - mortality
Liver Failure, Acute - therapy
Liver, Artificial
Probability
Random Allocation
Reference Values
Retrospective Studies
Risk Factors
Sensitivity and Specificity
Statistics, Nonparametric
Survival Rate
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Summary::  Life‐threatening, severely elevated intracranial pressure (ICP) is a common feature of acute liver failure (ALF). Perfusion with a bioartificial liver may serve to mitigate rising ICP. A retrospective analysis of ICP measurements in a canine ALF model prospectively supported with a bioartificial liver support system (BLSS) is presented. Animals are divided into two groups based upon care provided: (i) standard medical care (n = 6); and (ii) standard medical care plus BLSS support (n = 9). Nonparametric analysis with respect to ICP, arterial NH3, lactate, and supportive‐care parameters found BLSS‐supported animals evidenced significantly less metabolic acidosis than unsupported animals. Analysis of variance/linear regression for direct dependence of ICP on arterial NH3, lactate, and supportive care parameters irrespective of care found ICP was uncorrelated with any measured factor (P > 0.06 for all factors). Lack of correlation of ICP with the considered parameters indicates that none of these factors are predictive of the extent of ICP elevation in the d‐galactosamine canine model. Blood chemistry and supportive care factors that are correlated with and predictive of ICP elevation remain to be identified.
ISSN:0160-564X
1525-1594
DOI:10.1111/j.1525-1594.2007.00476.x