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Low levels of vitamin B12 and venous thromboembolic disease in elderly men
. Díaz de Tuesta AM, Ribó MaDR, Belinchón O, Marchena PJ, Bruscas MaJ, Val E, Cortés A, Nieto JA (Virgen de la Luz Hospital, Cuenca, Spain). Low levels of vitamin B12 and venous thromboembolic disease in elderly men. J Intern Med 2005; 258: 244–249. Objectives. Hyperhomocysteinaemia is a well‐know...
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| Published in: | Journal of internal medicine 2005-09, Vol.258 (3), p.244-249 |
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| container_title | Journal of internal medicine |
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| creator | DÍAZ DE TUESTA, A. M. RIBÓ, MA. D. R. BELINCHÓN, O. MARCHENA, P. J. BRUSCAS, MA. J. VAL, E. CORTÉS, A. NIETO, J. A. |
| description | . Díaz de Tuesta AM, Ribó MaDR, Belinchón O, Marchena PJ, Bruscas MaJ, Val E, Cortés A, Nieto JA (Virgen de la Luz Hospital, Cuenca, Spain). Low levels of vitamin B12 and venous thromboembolic disease in elderly men. J Intern Med 2005; 258: 244–249.
Objectives. Hyperhomocysteinaemia is a well‐known risk factor for venous thromboembolic disease (VTD). However, it is not clear whether homocysteine (Hc) itself or a related metabolite or a cofactor is primarily responsible for VTD. We carried out a case–control study to investigate whether vitamin concentrations that are involved in the Hc metabolism are associated or not with an elevated risk of VTD.
Design. Case–control study.
Methods. We measured serum vitamin B12, folate, creatinine and albumin concentrations and plasma Hc concentrations in 101 consecutive patients with VTD, diagnosed by image tests and 101 control subjects, matched for age and sex.
Results. Serum vitamin B12 concentrations were significantly lower in VTD patients than in the control subjects. There were no differences in plasma Hc or serum folate concentrations between the groups. Among the male subgroup aged more than 70 years, serum vitamin B12 concentrations were significantly lower (240.88 ± 103.07 vs. 421.20 ± 314.31 pmol L−1; P = 0.03) and plasma Hc concentrations were significantly higher (13.1 ± 4.18 vs. 10.56 ± 3.06 μmol L−1; P =0.04) in VTD patients than in the control group. On multivariate analysis, in patients aged more than 70 years, serum vitamin B12 concentrations were independently associated with VTD. Compared with the highest quartile of vitamin B12 (>512.6 pmol L−1) the odds ratio (OR) for VTD in the lowest quartile ( |
| doi_str_mv | 10.1111/j.1365-2796.2005.01527.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_68507212</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>897391861</sourcerecordid><originalsourceid>FETCH-LOGICAL-p2367-df41ccdf7496f5afd5d87386be81b151f17d223f173c758b3538304a67a303e43</originalsourceid><addsrcrecordid>eNpdkVtLwzAUgIMoOqd_QYKgb625NJe-CCpemexFn0PanGJH2s5mm-7fm7qp4AmHEzhfwuF8CGFKUhrjYpZSLkXCVC5TRohICRVMpZ87aPTb2EUjkosskZqRA3QYwowQyokk--iAShof5HqEnibdB_awAh9wV-FVvbBN3eJryrBtHV5B2y0DXrz1XVN0ENPXJXZ1ABsARxC8g96vcQPtEdqrrA9wvK1j9Hp3-3LzkEym9483V5NkzrhUiasyWpauUlkuK2ErJ5xWXMsCNC2ooBVVjjEeCy-V0AUXXHOSWaksJxwyPkbnm3_nffe-hLAwTR1K8N62EIc1UguiGGURPP0Hzrpl38bZDM1VPCwuZIxOttCyaMCZeV83tl-bnxVF4GwL2FBaX_W2LevwxykiNMtk5C433EftYf3XJ2ZQZmZmMGMGM2ZQZr6VmU_zNH18Hq78Cypah1o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>197979201</pqid></control><display><type>article</type><title>Low levels of vitamin B12 and venous thromboembolic disease in elderly men</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>DÍAZ DE TUESTA, A. M. ; RIBÓ, MA. D. R. ; BELINCHÓN, O. ; MARCHENA, P. J. ; BRUSCAS, MA. J. ; VAL, E. ; CORTÉS, A. ; NIETO, J. A.</creator><creatorcontrib>DÍAZ DE TUESTA, A. M. ; RIBÓ, MA. D. R. ; BELINCHÓN, O. ; MARCHENA, P. J. ; BRUSCAS, MA. J. ; VAL, E. ; CORTÉS, A. ; NIETO, J. A.</creatorcontrib><description>. Díaz de Tuesta AM, Ribó MaDR, Belinchón O, Marchena PJ, Bruscas MaJ, Val E, Cortés A, Nieto JA (Virgen de la Luz Hospital, Cuenca, Spain). Low levels of vitamin B12 and venous thromboembolic disease in elderly men. J Intern Med 2005; 258: 244–249.
Objectives. Hyperhomocysteinaemia is a well‐known risk factor for venous thromboembolic disease (VTD). However, it is not clear whether homocysteine (Hc) itself or a related metabolite or a cofactor is primarily responsible for VTD. We carried out a case–control study to investigate whether vitamin concentrations that are involved in the Hc metabolism are associated or not with an elevated risk of VTD.
Design. Case–control study.
Methods. We measured serum vitamin B12, folate, creatinine and albumin concentrations and plasma Hc concentrations in 101 consecutive patients with VTD, diagnosed by image tests and 101 control subjects, matched for age and sex.
Results. Serum vitamin B12 concentrations were significantly lower in VTD patients than in the control subjects. There were no differences in plasma Hc or serum folate concentrations between the groups. Among the male subgroup aged more than 70 years, serum vitamin B12 concentrations were significantly lower (240.88 ± 103.07 vs. 421.20 ± 314.31 pmol L−1; P = 0.03) and plasma Hc concentrations were significantly higher (13.1 ± 4.18 vs. 10.56 ± 3.06 μmol L−1; P =0.04) in VTD patients than in the control group. On multivariate analysis, in patients aged more than 70 years, serum vitamin B12 concentrations were independently associated with VTD. Compared with the highest quartile of vitamin B12 (>512.6 pmol L−1) the odds ratio (OR) for VTD in the lowest quartile (<230.9 pmol L−1) was 3.8 (95% CI 1.44–10.18; P = 0.01).
In the VTD group, lowest vitamin B12 concentrations (percentile 10 <152.8 pmol L−1) were associated with the factor V Leiden mutation (OR = 6.07, 95% CI 0.93–38.55; P = 0.04).
Conclusions. Measuring vitamin B12 concentrations in elderly males may help in identifying people at risk of venous thromboembolism in our population.</description><identifier>ISSN: 0954-6820</identifier><identifier>EISSN: 1365-2796</identifier><identifier>DOI: 10.1111/j.1365-2796.2005.01527.x</identifier><identifier>PMID: 16115298</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Age Factors ; Aged ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Case-Control Studies ; Creatinine - blood ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; factor V Leiden ; Female ; Folic Acid - blood ; General aspects ; homocysteine ; Homocysteine - blood ; Humans ; Logistic Models ; Male ; Medical sciences ; pulmonary embolism ; Risk Assessment ; Thromboembolism - etiology ; venous thrombosis ; Venous Thrombosis - blood ; Venous Thrombosis - etiology ; Vitamin B 12 - blood ; Vitamin B Deficiency - blood ; Vitamin B Deficiency - complications ; vitamin B12</subject><ispartof>Journal of internal medicine, 2005-09, Vol.258 (3), p.244-249</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Sep 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17058246$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16115298$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DÍAZ DE TUESTA, A. M.</creatorcontrib><creatorcontrib>RIBÓ, MA. D. R.</creatorcontrib><creatorcontrib>BELINCHÓN, O.</creatorcontrib><creatorcontrib>MARCHENA, P. J.</creatorcontrib><creatorcontrib>BRUSCAS, MA. J.</creatorcontrib><creatorcontrib>VAL, E.</creatorcontrib><creatorcontrib>CORTÉS, A.</creatorcontrib><creatorcontrib>NIETO, J. A.</creatorcontrib><title>Low levels of vitamin B12 and venous thromboembolic disease in elderly men</title><title>Journal of internal medicine</title><addtitle>J Intern Med</addtitle><description>. Díaz de Tuesta AM, Ribó MaDR, Belinchón O, Marchena PJ, Bruscas MaJ, Val E, Cortés A, Nieto JA (Virgen de la Luz Hospital, Cuenca, Spain). Low levels of vitamin B12 and venous thromboembolic disease in elderly men. J Intern Med 2005; 258: 244–249.
Objectives. Hyperhomocysteinaemia is a well‐known risk factor for venous thromboembolic disease (VTD). However, it is not clear whether homocysteine (Hc) itself or a related metabolite or a cofactor is primarily responsible for VTD. We carried out a case–control study to investigate whether vitamin concentrations that are involved in the Hc metabolism are associated or not with an elevated risk of VTD.
Design. Case–control study.
Methods. We measured serum vitamin B12, folate, creatinine and albumin concentrations and plasma Hc concentrations in 101 consecutive patients with VTD, diagnosed by image tests and 101 control subjects, matched for age and sex.
Results. Serum vitamin B12 concentrations were significantly lower in VTD patients than in the control subjects. There were no differences in plasma Hc or serum folate concentrations between the groups. Among the male subgroup aged more than 70 years, serum vitamin B12 concentrations were significantly lower (240.88 ± 103.07 vs. 421.20 ± 314.31 pmol L−1; P = 0.03) and plasma Hc concentrations were significantly higher (13.1 ± 4.18 vs. 10.56 ± 3.06 μmol L−1; P =0.04) in VTD patients than in the control group. On multivariate analysis, in patients aged more than 70 years, serum vitamin B12 concentrations were independently associated with VTD. Compared with the highest quartile of vitamin B12 (>512.6 pmol L−1) the odds ratio (OR) for VTD in the lowest quartile (<230.9 pmol L−1) was 3.8 (95% CI 1.44–10.18; P = 0.01).
In the VTD group, lowest vitamin B12 concentrations (percentile 10 <152.8 pmol L−1) were associated with the factor V Leiden mutation (OR = 6.07, 95% CI 0.93–38.55; P = 0.04).
Conclusions. Measuring vitamin B12 concentrations in elderly males may help in identifying people at risk of venous thromboembolism in our population.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Creatinine - blood</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>factor V Leiden</subject><subject>Female</subject><subject>Folic Acid - blood</subject><subject>General aspects</subject><subject>homocysteine</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>pulmonary embolism</subject><subject>Risk Assessment</subject><subject>Thromboembolism - etiology</subject><subject>venous thrombosis</subject><subject>Venous Thrombosis - blood</subject><subject>Venous Thrombosis - etiology</subject><subject>Vitamin B 12 - blood</subject><subject>Vitamin B Deficiency - blood</subject><subject>Vitamin B Deficiency - complications</subject><subject>vitamin B12</subject><issn>0954-6820</issn><issn>1365-2796</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNpdkVtLwzAUgIMoOqd_QYKgb625NJe-CCpemexFn0PanGJH2s5mm-7fm7qp4AmHEzhfwuF8CGFKUhrjYpZSLkXCVC5TRohICRVMpZ87aPTb2EUjkosskZqRA3QYwowQyokk--iAShof5HqEnibdB_awAh9wV-FVvbBN3eJryrBtHV5B2y0DXrz1XVN0ENPXJXZ1ABsARxC8g96vcQPtEdqrrA9wvK1j9Hp3-3LzkEym9483V5NkzrhUiasyWpauUlkuK2ErJ5xWXMsCNC2ooBVVjjEeCy-V0AUXXHOSWaksJxwyPkbnm3_nffe-hLAwTR1K8N62EIc1UguiGGURPP0Hzrpl38bZDM1VPCwuZIxOttCyaMCZeV83tl-bnxVF4GwL2FBaX_W2LevwxykiNMtk5C433EftYf3XJ2ZQZmZmMGMGM2ZQZr6VmU_zNH18Hq78Cypah1o</recordid><startdate>200509</startdate><enddate>200509</enddate><creator>DÍAZ DE TUESTA, A. M.</creator><creator>RIBÓ, MA. D. R.</creator><creator>BELINCHÓN, O.</creator><creator>MARCHENA, P. J.</creator><creator>BRUSCAS, MA. J.</creator><creator>VAL, E.</creator><creator>CORTÉS, A.</creator><creator>NIETO, J. A.</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200509</creationdate><title>Low levels of vitamin B12 and venous thromboembolic disease in elderly men</title><author>DÍAZ DE TUESTA, A. M. ; RIBÓ, MA. D. R. ; BELINCHÓN, O. ; MARCHENA, P. J. ; BRUSCAS, MA. J. ; VAL, E. ; CORTÉS, A. ; NIETO, J. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2367-df41ccdf7496f5afd5d87386be81b151f17d223f173c758b3538304a67a303e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Creatinine - blood</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>factor V Leiden</topic><topic>Female</topic><topic>Folic Acid - blood</topic><topic>General aspects</topic><topic>homocysteine</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>pulmonary embolism</topic><topic>Risk Assessment</topic><topic>Thromboembolism - etiology</topic><topic>venous thrombosis</topic><topic>Venous Thrombosis - blood</topic><topic>Venous Thrombosis - etiology</topic><topic>Vitamin B 12 - blood</topic><topic>Vitamin B Deficiency - blood</topic><topic>Vitamin B Deficiency - complications</topic><topic>vitamin B12</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DÍAZ DE TUESTA, A. M.</creatorcontrib><creatorcontrib>RIBÓ, MA. D. R.</creatorcontrib><creatorcontrib>BELINCHÓN, O.</creatorcontrib><creatorcontrib>MARCHENA, P. J.</creatorcontrib><creatorcontrib>BRUSCAS, MA. J.</creatorcontrib><creatorcontrib>VAL, E.</creatorcontrib><creatorcontrib>CORTÉS, A.</creatorcontrib><creatorcontrib>NIETO, J. A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DÍAZ DE TUESTA, A. M.</au><au>RIBÓ, MA. D. R.</au><au>BELINCHÓN, O.</au><au>MARCHENA, P. J.</au><au>BRUSCAS, MA. J.</au><au>VAL, E.</au><au>CORTÉS, A.</au><au>NIETO, J. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low levels of vitamin B12 and venous thromboembolic disease in elderly men</atitle><jtitle>Journal of internal medicine</jtitle><addtitle>J Intern Med</addtitle><date>2005-09</date><risdate>2005</risdate><volume>258</volume><issue>3</issue><spage>244</spage><epage>249</epage><pages>244-249</pages><issn>0954-6820</issn><eissn>1365-2796</eissn><abstract>. Díaz de Tuesta AM, Ribó MaDR, Belinchón O, Marchena PJ, Bruscas MaJ, Val E, Cortés A, Nieto JA (Virgen de la Luz Hospital, Cuenca, Spain). Low levels of vitamin B12 and venous thromboembolic disease in elderly men. J Intern Med 2005; 258: 244–249.
Objectives. Hyperhomocysteinaemia is a well‐known risk factor for venous thromboembolic disease (VTD). However, it is not clear whether homocysteine (Hc) itself or a related metabolite or a cofactor is primarily responsible for VTD. We carried out a case–control study to investigate whether vitamin concentrations that are involved in the Hc metabolism are associated or not with an elevated risk of VTD.
Design. Case–control study.
Methods. We measured serum vitamin B12, folate, creatinine and albumin concentrations and plasma Hc concentrations in 101 consecutive patients with VTD, diagnosed by image tests and 101 control subjects, matched for age and sex.
Results. Serum vitamin B12 concentrations were significantly lower in VTD patients than in the control subjects. There were no differences in plasma Hc or serum folate concentrations between the groups. Among the male subgroup aged more than 70 years, serum vitamin B12 concentrations were significantly lower (240.88 ± 103.07 vs. 421.20 ± 314.31 pmol L−1; P = 0.03) and plasma Hc concentrations were significantly higher (13.1 ± 4.18 vs. 10.56 ± 3.06 μmol L−1; P =0.04) in VTD patients than in the control group. On multivariate analysis, in patients aged more than 70 years, serum vitamin B12 concentrations were independently associated with VTD. Compared with the highest quartile of vitamin B12 (>512.6 pmol L−1) the odds ratio (OR) for VTD in the lowest quartile (<230.9 pmol L−1) was 3.8 (95% CI 1.44–10.18; P = 0.01).
In the VTD group, lowest vitamin B12 concentrations (percentile 10 <152.8 pmol L−1) were associated with the factor V Leiden mutation (OR = 6.07, 95% CI 0.93–38.55; P = 0.04).
Conclusions. Measuring vitamin B12 concentrations in elderly males may help in identifying people at risk of venous thromboembolism in our population.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>16115298</pmid><doi>10.1111/j.1365-2796.2005.01527.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Age Factors Aged Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels Cardiology. Vascular system Case-Control Studies Creatinine - blood Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous factor V Leiden Female Folic Acid - blood General aspects homocysteine Homocysteine - blood Humans Logistic Models Male Medical sciences pulmonary embolism Risk Assessment Thromboembolism - etiology venous thrombosis Venous Thrombosis - blood Venous Thrombosis - etiology Vitamin B 12 - blood Vitamin B Deficiency - blood Vitamin B Deficiency - complications vitamin B12 |
| title | Low levels of vitamin B12 and venous thromboembolic disease in elderly men |
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