Selective antitumor activity of lymphokine-activated killer cells in vitro

We compared cytotoxic activity of blood mononuclear leukocytes from healthy donors and lymphokine-activated killer cells generated from them towards tumor and normal cells. Lymphokine-activated killer cells exhibited higher (in comparison with blood mononuclear leukocytes) killer activity towards tu...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2007-01, Vol.143 (1), p.132-135
Main Authors: Zhukova, O S, Lebedinskaya, O V, Shubina, I Zh, Gerasimova, G K, Karamzin, A M, Kiselevskii, M V
Format: Article
Language:English
Subjects:
Cell Line
Cell Line, Tumor
Cytotoxicity, Immunologic
Humans
Immunophenotyping
Killer Cells, Lymphokine-Activated - immunology
Leukocytes, Mononuclear - immunology
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Summary:We compared cytotoxic activity of blood mononuclear leukocytes from healthy donors and lymphokine-activated killer cells generated from them towards tumor and normal cells. Lymphokine-activated killer cells exhibited higher (in comparison with blood mononuclear leukocytes) killer activity towards tumor cells. Lymphokine-activated cells and mononuclear leukocytes had no lytic effect on non-transformed eukaryotic cells. Hence, we demonstrated selective cytotoxic activity of effector cells (lymphokine-activated killers) towards tumor cells of different origin (but not normal cells).
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-007-0033-y