Comparative genomic hybridisation identifies two variants of smoldering multiple myeloma

Summary Two variants of smoldering multiple myeloma (SMM) have been recognised: (i) an evolving type, characterised by a progressive increase in the M‐protein size and short time to progression to overt multiple myeloma (MM) and (ii) a non‐evolving type, with a long‐lasting, stable M‐protein and lon...

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Bibliographic Details
Published in:British journal of haematology 2005-09, Vol.130 (5), p.729-732
Main Authors: Rosiñol, Laura, Carrió, Ana, Bladé, Joan, Queralt, Rosa, Aymerich, Marta, Cibeira, MaTeresa, Esteve, Jordi, Rozman, Maria, Campo, Elías, Montserrat, Emili
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bone Marrow Examination
Chromosome Aberrations
Chromosomes, Human, Pair 13
comparative genomic hybridisation
Disease Progression
Gene Deletion
Hematologic and hematopoietic diseases
Hematology
Humans
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulinopathies
Immunopathology
In Situ Hybridization, Fluorescence
Interphase
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
multiple myeloma
Multiple Myeloma - classification
Multiple Myeloma - genetics
Myeloma Proteins - genetics
Prognosis
smoldering multiple myeloma
transformation
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Summary:Summary Two variants of smoldering multiple myeloma (SMM) have been recognised: (i) an evolving type, characterised by a progressive increase in the M‐protein size and short time to progression to overt multiple myeloma (MM) and (ii) a non‐evolving type, with a long‐lasting, stable M‐protein and longer time to progression. Comparative genomic hybridisation (CGH) analyses in both subtypes of SMM (seven evolving and eight non‐evolving SMM) were performed. Evolving SMM showed cytogenetic changes consistent with those found in de novo symptomatic MM (1q gains, chromosome 13 deletions) while the non‐evolving variant showed no 1q gains and deletions were uncommon.
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2005.05673.x