Structural and functional changes in epitheliocytes of collecting tubes in renal papilla of Brattleboro rats treated with vasopressin

The functional response of the kidney to desmopressin and morphological changes in epitheliocytes of collecting tubes were studied on homozygotic Brattleboro rats. Redistribution of beta-glucuronidase fractions and increase in the number of osmiophilic granules reflecting increased production of vas...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2007-01, Vol.143 (1), p.94-98
Main Authors: Ivanova, L N, Lavrinenko, V A, Shestopalova, L V, Korotkova, S M
Format: Article
Language:English
Subjects:
Animals
Deamino Arginine Vasopressin - pharmacology
Glucuronidase - metabolism
Histocytochemistry
Homozygote
Kidney Medulla - cytology
Kidney Medulla - physiology
Kidney Medulla - ultrastructure
Kidney Tubules, Collecting - cytology
Kidney Tubules, Collecting - physiology
Kidney Tubules, Collecting - ultrastructure
Osmolar Concentration
Rats
Rats, Brattleboro
Receptors, Vasopressin - agonists
Urodynamics
Urothelium - cytology
Urothelium - physiology
Urothelium - ultrastructure
Vasopressins - genetics
Vasopressins - physiology
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Summary:The functional response of the kidney to desmopressin and morphological changes in epitheliocytes of collecting tubes were studied on homozygotic Brattleboro rats. Redistribution of beta-glucuronidase fractions and increase in the number of osmiophilic granules reflecting increased production of vasopressin-dependent proteins and hyaluronate hydrolase exocytosis were typical structural correlates of the effect of vasopressin.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-007-0026-x