Statistical analysis of six STR loci located in MHC region in Iranian population for preimplantation genetic diagnosis

Summary We studied allele frequency and other statistical parameters of six short‐tandem repeat (STR) loci: D6S265, D6S439, D6S105, D6S82‐1, MICA, and MOGd, which are located in major histocompatibility complex (MHC) region (6p21.3) in 101 Iranian individuals. STR polymorphisms were analysed by PCR...

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Bibliographic Details
Published in:International Journal of Immunogenetics 2007-12, Vol.34 (6), p.441-443
Main Authors: Korzebor, A., Zamani, M., Nouri, K., Modarressi, M. H.
Format: Article
Language:English
Subjects:
Alleles
Gene Frequency
Genetic Markers
Genetics, Population
Humans
Iran
Major Histocompatibility Complex - genetics
Microsatellite Repeats - genetics
Polymorphism, Genetic
Preimplantation Diagnosis
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Summary:Summary We studied allele frequency and other statistical parameters of six short‐tandem repeat (STR) loci: D6S265, D6S439, D6S105, D6S82‐1, MICA, and MOGd, which are located in major histocompatibility complex (MHC) region (6p21.3) in 101 Iranian individuals. STR polymorphisms were analysed by PCR and polyacrylamide gel electrophoresis and subsequent comparison with standard (allelic) ladders. Exact tests of Hardy–Weinberg equilibrium were performed for the six loci. All loci, except the MOGd (P = 0.4291), were in Hardy–Weinberg equilibrium. These data may be useful in PGD‐HLA matching and forensic science.
ISSN:1744-3121
1744-313X
1365-2370
DOI:10.1111/j.1744-313X.2007.00719.x