Epidural compression in neuroblastoma: Diagnostic and therapeutic aspects

The involvement by tumour of intervertebral foramina and the consequent invasion of the spinal space, accompanied or not by neurological symptoms, represent a well-recognised pattern of presentation of neuroblastoma. The main peculiarity of this condition stands in the fact that, in case of its late...

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Bibliographic Details
Published in:Cancer letters 2005-10, Vol.228 (1), p.283-299
Main Authors: Bernardi, Bruno De, Balwierz, Walentyna, Bejent, Joanna, Cohn, Susan L., Garrè, Maria Luisa, Iehara, Tomoko, Plantaz, Dominique, Simon, Thorsten, Angelini, Paola, Cama, Armando, London, Wendy B., Kramer, Kim, Katzenstein, Howard M., Tortori-Donati, Paolo, Rossi, Andrea, D'Angio, Giulio J., Evans, Audrey E.
Format: Article
Language:English
Subjects:
Advantages
Antineoplastic Agents - therapeutic use
Diagnostic Imaging
Epidural compression
Female
Humans
Infant
Late effects
Male
Neuroblastoma
Neuroblastoma - complications
Neurosurgery
Patients
Radiation therapy
Radiotherapy
Scoliosis
Spinal cord
Spinal cord compression
Spinal Cord Compression - complications
Spinal Cord Compression - diagnosis
Spinal Cord Compression - therapy
Surgery
Treatment Outcome
Tumors
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Description
Summary:The involvement by tumour of intervertebral foramina and the consequent invasion of the spinal space, accompanied or not by neurological symptoms, represent a well-recognised pattern of presentation of neuroblastoma. The main peculiarity of this condition stands in the fact that, in case of its late detection or inadequate treatment, severe, permanent neurological compromise may ensue. Surprisingly enough, remarkable disagreements still exist regarding its optimal treatment and the related literature provide contrasting indications at this respect. The neurosurgical and the chemotherapeutic approaches have equally convinced supporters, while the use of radiation therapy is uncommon, possibly without good reasons. This mini-review intends to report the clinical experiences of the major Paediatric Oncology Groups with the aim to collect as many data as possible in the perspective of establishing common guidelines for proper diagnosing and treatment of this important complication.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2005.01.053