PohnB6F1: A Cross of Wild and Domestic Mice That Is a New Model of Extended Female Reproductive Life Span

In the search for novel genetic diversity that affects the timing of life history traits, we investigated a wild-derived stock of mice (Pohn). Early generations showed extended reproductive life span; however, this phenotype diminished with propagation of the stock. Out-crossing latter generation Po...

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Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2007-11, Vol.62 (11), p.1187-1198
Main Authors: Flurkey, Kevin, Brandvain, Yaniv, Klebanov, Simon, Austad, Steven N., Miller, Richard A., Yuan, Rong, Harrison, David E.
Format: Article
Language:English
Subjects:
Aging - physiology
Analysis of Variance
Animals
Animals, Laboratory
Animals, Wild
Body Weight
Crosses, Genetic
Female
Litter Size
Longevity - genetics
Mice
Mice, Inbred C57BL
Mice, Inbred Strains - genetics
Oocytes
Phenotype
Reproduction - physiology
Selection, Genetic
Sexual Maturation - genetics
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Summary:In the search for novel genetic diversity that affects the timing of life history traits, we investigated a wild-derived stock of mice (Pohn). Early generations showed extended reproductive life span; however, this phenotype diminished with propagation of the stock. Out-crossing latter generation Pohn mice to C57BL/6J (B6) mice produced PohnB6F1 hybrids with remarkably extended reproductive life spans—mean age at last litter of 647 ± 32 days—longer than for the parental strains (70% longer than Pohn, 88% longer than B6) and longer than for highly heterogeneous crosses of laboratory mice. Litter size among young PohnB6F1 adults was similar to parental stocks, but their age-related decline in litter size was delayed by 150–200 days, resembling the earlier Pohn generations. Possibly, out-crossing Pohn mice unmasked cryptic alleles that promote extended female reproduction. This work establishes the PohnB6F1 hybrid as a new model for delayed reproductive aging.
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/62.11.1187