PohnB6F1: A Cross of Wild and Domestic Mice That Is a New Model of Extended Female Reproductive Life Span

In the search for novel genetic diversity that affects the timing of life history traits, we investigated a wild-derived stock of mice (Pohn). Early generations showed extended reproductive life span; however, this phenotype diminished with propagation of the stock. Out-crossing latter generation Po...

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Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2007-11, Vol.62 (11), p.1187-1198
Main Authors: Flurkey, Kevin, Brandvain, Yaniv, Klebanov, Simon, Austad, Steven N., Miller, Richard A., Yuan, Rong, Harrison, David E.
Format: Article
Language:English
Subjects:
Aging - physiology
Analysis of Variance
Animals
Animals, Laboratory
Animals, Wild
Body Weight
Crosses, Genetic
Female
Litter Size
Longevity - genetics
Mice
Mice, Inbred C57BL
Mice, Inbred Strains - genetics
Oocytes
Phenotype
Reproduction - physiology
Selection, Genetic
Sexual Maturation - genetics
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cited_by cdi_FETCH-LOGICAL-c407t-3cbaed85e5f10fc3c37516df741b4f558898fbbb718f3b2187e405eb244a61533
cites cdi_FETCH-LOGICAL-c407t-3cbaed85e5f10fc3c37516df741b4f558898fbbb718f3b2187e405eb244a61533
container_end_page 1198
container_issue 11
container_start_page 1187
container_title The journals of gerontology. Series A, Biological sciences and medical sciences
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creator Flurkey, Kevin
Brandvain, Yaniv
Klebanov, Simon
Austad, Steven N.
Miller, Richard A.
Yuan, Rong
Harrison, David E.
description In the search for novel genetic diversity that affects the timing of life history traits, we investigated a wild-derived stock of mice (Pohn). Early generations showed extended reproductive life span; however, this phenotype diminished with propagation of the stock. Out-crossing latter generation Pohn mice to C57BL/6J (B6) mice produced PohnB6F1 hybrids with remarkably extended reproductive life spans—mean age at last litter of 647 ± 32 days—longer than for the parental strains (70% longer than Pohn, 88% longer than B6) and longer than for highly heterogeneous crosses of laboratory mice. Litter size among young PohnB6F1 adults was similar to parental stocks, but their age-related decline in litter size was delayed by 150–200 days, resembling the earlier Pohn generations. Possibly, out-crossing Pohn mice unmasked cryptic alleles that promote extended female reproduction. This work establishes the PohnB6F1 hybrid as a new model for delayed reproductive aging.
doi_str_mv 10.1093/gerona/62.11.1187
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ispartof The journals of gerontology. Series A, Biological sciences and medical sciences, 2007-11, Vol.62 (11), p.1187-1198
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1758-535X
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source Oxford Journals Online
subjects Aging - physiology
Analysis of Variance
Animals
Animals, Laboratory
Animals, Wild
Body Weight
Crosses, Genetic
Female
Litter Size
Longevity - genetics
Mice
Mice, Inbred C57BL
Mice, Inbred Strains - genetics
Oocytes
Phenotype
Reproduction - physiology
Selection, Genetic
Sexual Maturation - genetics
title PohnB6F1: A Cross of Wild and Domestic Mice That Is a New Model of Extended Female Reproductive Life Span
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