Determination of hydrochlorothiazide and irbesartan in pharmaceuticals by fourth-order UV derivative spectrophotometry

The fourth-order derivative spectrum from the alcoholic sample is used. HCT can be determined by a specific peak–trough, of low intensity, at 330–340 nm. For IST evaluation, a peak–trough around 250–310 nm is available, common to both products, whose amplitude increases linearly only for low concent...

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Bibliographic Details
Published in:Farmaco (Società chimica italiana : 1989) 2005-08, Vol.60 (8), p.665-670
Main Authors: Vetuschi, C., Giannandrea, A., Carlucci, G., Mazzeo, P.
Format: Article
Language:English
Subjects:
Antihypertensive analysis
Biphenyl Compounds - analysis
Derivative spectrophotometry
Hydrochlorothiazide
Hydrochlorothiazide - analysis
Irbesartan
Molecular Structure
Multiple linear regression
Pharmaceutical Preparations - chemistry
Spectrophotometry, Ultraviolet - methods
Tetrazoles - analysis
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Summary:The fourth-order derivative spectrum from the alcoholic sample is used. HCT can be determined by a specific peak–trough, of low intensity, at 330–340 nm. For IST evaluation, a peak–trough around 250–310 nm is available, common to both products, whose amplitude increases linearly only for low concentration values, while it decreases at higher values. The most difficult aspect of the analysis lies in how to find the optimal concentration range, so that both signals can be evaluated simultaneously. The best results were achieved by using a linear regression for HCT and a regression plane for IST.
ISSN:0014-827X
1879-0569
DOI:10.1016/j.farmac.2005.04.013