Synthesis, spectroscopic and biological properties of bis(3-arylimidazolidinyl-1)methanes. A novel family of antimicrobial agents

Synthesis, spectroscopic and biological properties of new bis(3-arylimidazolidinyl-1)methanes are described. These compounds were synthesized by condensation reaction between N-arylethylenediamines and formaldehyde. Chemical structures were confirmed by means of their 1H- and 13C-NMR and mass spectr...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2005-08, Vol.40 (8), p.811-815
Main Authors: Perillo, Isabel, Repetto, Evangelina, Caterina, María Cristina, Massa, Rosana, Gutkind, Gabriel, Salerno, Alejandra
Format: Article
Language:English
Subjects:
Aminals
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antimicrobial activity
Biological and medical sciences
Bis(3-arylimidazolidinyl-1)methanes
Ethylenediamines - chemistry
Formaldehyde - chemistry
General aspects
Imidazoles - chemical synthesis
Imidazoles - chemistry
Imidazoles - pharmacology
Imidazolidines
Magnetic Resonance Spectroscopy
Mass Spectrometry
Medical sciences
Methane - analogs & derivatives
Methane - chemistry
Methane - pharmacology
Microbial Sensitivity Tests
Pharmacology. Drug treatments
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Summary:Synthesis, spectroscopic and biological properties of new bis(3-arylimidazolidinyl-1)methanes are described. These compounds were synthesized by condensation reaction between N-arylethylenediamines and formaldehyde. Chemical structures were confirmed by means of their 1H- and 13C-NMR and mass spectroscopic data. Investigation of in vitro antimicrobial activity was performed using Gram-negative and Gram-positive bacteria as well as antifungal studies against Aspergillus niger and Candida albicans. Minimal inhibitory concentrations of active compounds were determined.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2005.03.010