Inhibition of RNA Polymerase by Streptolydigin: No Cycling Allowed

Bacterial RNA polymerase is a common target for many antibiotics. In two recent papers in Cell and Molecular Cell, Tuske et al. (2005) and Temiakov et al. (2005) describe a structural basis for inhibition of bacterial RNA polymerase by the antibiotic streptolydigin. Streptolydigin may prevent distor...

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Bibliographic Details
Published in:Cell 2005-08, Vol.122 (4), p.494-496
Main Authors: Kyzer, Scotty, Zhang, Jinwei, Landick, Robert
Format: Article
Language:English
Subjects:
Aminoglycosides - pharmacology
Bacteria - enzymology
DNA-Directed RNA Polymerases - antagonists & inhibitors
DNA-Directed RNA Polymerases - metabolism
Feedback, Physiological
Models, Molecular
Nucleotides - metabolism
Phosphorylation
Protein Structure, Secondary - drug effects
Protein Structure, Secondary - physiology
RNA - biosynthesis
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Summary:Bacterial RNA polymerase is a common target for many antibiotics. In two recent papers in Cell and Molecular Cell, Tuske et al. (2005) and Temiakov et al. (2005) describe a structural basis for inhibition of bacterial RNA polymerase by the antibiotic streptolydigin. Streptolydigin may prevent distortion of a “bridge” α helix postulated to occur during the nucleotide addition cycle of RNA polymerase or may block a small movement of the bridge helix that helps load nucleotide triphosphates into the active site.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2005.08.008