Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities

Adrenomedullin (AM) is a 52-amino acid peptide with a pluripotential activity. AM is expressed in many tissues throughout the body, and plays a critical role in several diseases such as cancer, diabetes, cardiovascular and renal disorders, among others. While AM is a protective agent against cardiov...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2005-08, Vol.40 (8), p.737-750
Main Authors: Julián, Miguel, Cacho, Mónica, García, Mario A., Martín-Santamaría, Sonsoles, de Pascual-Teresa, Beatriz, Ramos, Ana, Martínez, Alfredo, Cuttitta, Frank
Format: Article
Language:English
Subjects:
Adrenomedullin
Amino Acid Sequence
Animals
Antihypertensive Agents - pharmacology
Biological and medical sciences
Cancer
Cardiovascular Diseases - drug therapy
Diabetes
Diabetes Mellitus - drug therapy
Drug Design
Humans
Hypertension
Medical sciences
Miscellaneous
Molecular Sequence Data
Neoplasms - drug therapy
Peptides - drug effects
Peptides - physiology
Pharmacology. Drug treatments
Positive and negative modulators
Sequence Alignment
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Summary:Adrenomedullin (AM) is a 52-amino acid peptide with a pluripotential activity. AM is expressed in many tissues throughout the body, and plays a critical role in several diseases such as cancer, diabetes, cardiovascular and renal disorders, among others. While AM is a protective agent against cardiovascular disorders, it behaves as a stimulating factor in other pathologies such as cancer and diabetes. Therefore, AM is a new and promising target for the development of molecules which, through their ability to regulate AM levels, could be used in the treatment of these pathologies.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2004.10.016