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Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities

Adrenomedullin (AM) is a 52-amino acid peptide with a pluripotential activity. AM is expressed in many tissues throughout the body, and plays a critical role in several diseases such as cancer, diabetes, cardiovascular and renal disorders, among others. While AM is a protective agent against cardiov...

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Published in:	European journal of medicinal chemistry 2005-08, Vol.40 (8), p.737-750
Main Authors:	Julián, Miguel, Cacho, Mónica, García, Mario A., Martín-Santamaría, Sonsoles, de Pascual-Teresa, Beatriz, Ramos, Ana, Martínez, Alfredo, Cuttitta, Frank
Format:	Article
Language:	English
Subjects:	Adrenomedullin Amino Acid Sequence Animals Antihypertensive Agents - pharmacology Biological and medical sciences Cancer Cardiovascular Diseases - drug therapy Diabetes Diabetes Mellitus - drug therapy Drug Design Humans Hypertension Medical sciences Miscellaneous Molecular Sequence Data Neoplasms - drug therapy Peptides - drug effects Peptides - physiology Pharmacology. Drug treatments Positive and negative modulators Sequence Alignment
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cited_by	cdi_FETCH-LOGICAL-c390t-bb33b80d807f35eca5645a2427bbc2c4241effab0c5086844c23816c58f7d90b3
cites	cdi_FETCH-LOGICAL-c390t-bb33b80d807f35eca5645a2427bbc2c4241effab0c5086844c23816c58f7d90b3
container_end_page	750
container_issue	8
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container_title	European journal of medicinal chemistry
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creator	Julián, Miguel Cacho, Mónica García, Mario A. Martín-Santamaría, Sonsoles de Pascual-Teresa, Beatriz Ramos, Ana Martínez, Alfredo Cuttitta, Frank
description	Adrenomedullin (AM) is a 52-amino acid peptide with a pluripotential activity. AM is expressed in many tissues throughout the body, and plays a critical role in several diseases such as cancer, diabetes, cardiovascular and renal disorders, among others. While AM is a protective agent against cardiovascular disorders, it behaves as a stimulating factor in other pathologies such as cancer and diabetes. Therefore, AM is a new and promising target for the development of molecules which, through their ability to regulate AM levels, could be used in the treatment of these pathologies.
doi_str_mv	10.1016/j.ejmech.2004.10.016
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Therefore, AM is a new and promising target for the development of molecules which, through their ability to regulate AM levels, could be used in the treatment of these pathologies.</description><subject>Adrenomedullin</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Cardiovascular Diseases - drug therapy</subject><subject>Diabetes</subject><subject>Diabetes Mellitus - drug therapy</subject><subject>Drug Design</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>Neoplasms - drug therapy</subject><subject>Peptides - drug effects</subject><subject>Peptides - physiology</subject><subject>Pharmacology. 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source	ScienceDirect Freedom Collection 2022-2024
subjects	Adrenomedullin Amino Acid Sequence Animals Antihypertensive Agents - pharmacology Biological and medical sciences Cancer Cardiovascular Diseases - drug therapy Diabetes Diabetes Mellitus - drug therapy Drug Design Humans Hypertension Medical sciences Miscellaneous Molecular Sequence Data Neoplasms - drug therapy Peptides - drug effects Peptides - physiology Pharmacology. Drug treatments Positive and negative modulators Sequence Alignment
title	Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities
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