Synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-one/thione-5-one derivatives and evaluation as antibacterials

A novel, ecofriendly, one pot solvent free method for the synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-one/thione-5-one derivatives is described which devoids the use of any organic solvents and auxiliaries. All the synthesized compounds were screened for their in vitro an...

Full description

Saved in:
Bibliographic Details
Published in:European journal of medicinal chemistry 2005-08, Vol.40 (8), p.816-819
Main Authors: Kidwai, M., Saxena, S., Khan, M. Khalilur Rahman, Thukral, S.S.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Medical sciences
Microbial Sensitivity Tests
Microwave irradiation
Norfloxacin - pharmacology
Pharmacology. Drug treatments
Quinazolines
Quinazolines - chemical synthesis
Quinazolines - chemistry
Quinazolines - pharmacology
Solvent free
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A novel, ecofriendly, one pot solvent free method for the synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-one/thione-5-one derivatives is described which devoids the use of any organic solvents and auxiliaries. All the synthesized compounds were screened for their in vitro antibacterial activity against standard strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2005.02.009