Oppenauer Oxidation of Secondary Alcohols with 1,1,1-Trifluoroacetone as Hydride Acceptor

1,1,1-Trifluoroacetone (2a) reacts as a hydride-acceptor in the Oppenauer oxidation of secondary alcohols (1) in the presence of diethylethoxyaluminum. The oxidant allows for selective oxidation of secondary alcohols in the presence of primary alcohols.

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Bibliographic Details
Published in:Journal of organic chemistry 2007-11, Vol.72 (24), p.9376-9378
Main Authors: Mello, Rossella, Martínez-Ferrer, Jaime, Asensio, Gregorio, González-Núñez, María Elena
Format: Article
Language:English
Subjects:
Chemistry
Exact sciences and technology
Organic chemistry
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Summary:1,1,1-Trifluoroacetone (2a) reacts as a hydride-acceptor in the Oppenauer oxidation of secondary alcohols (1) in the presence of diethylethoxyaluminum. The oxidant allows for selective oxidation of secondary alcohols in the presence of primary alcohols.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo7016422