Ghrelin enhances the nocturnal secretion of cortisol and growth hormone in young females without influencing sleep

Summary Ghrelin was shown to increase slow wave sleep (SWS) and the secretion of growth hormone (GH) and cortisol in young males. In terms of sleep, such information for females, however, is lacking. Therefore, polysomnographies were recorded (23:00–07:00 h) and nocturnal (20:00–07:00 h) secretion p...

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Published in:Psychoneuroendocrinology 2007-09, Vol.32 (8), p.1079-1085
Main Authors: Kluge, Michael, Schüssler, Petra, Zuber, Verena, Kleyer, Sara, Yassouridis, Alexander, Dresler, Martin, Uhr, Manfred, Steiger, Axel
Format: Article
Language:English
Subjects:
Adult
Behavioral psychophysiology
Biological and medical sciences
Circadian Rhythm - drug effects
Cortisol
Cross-Over Studies
Endocrinology & Metabolism
Female
Fundamental and applied biological sciences. Psychology
Gender
Ghrelin
Ghrelin - pharmacology
Growth hormone
Growth Hormone - secretion
Hormones and behavior
Humans
Hydrocortisone - secretion
Placebos
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Single-Blind Method
Sleep
Sleep - drug effects
Sleep - physiology
Up-Regulation
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Summary:Summary Ghrelin was shown to increase slow wave sleep (SWS) and the secretion of growth hormone (GH) and cortisol in young males. In terms of sleep, such information for females, however, is lacking. Therefore, polysomnographies were recorded (23:00–07:00 h) and nocturnal (20:00–07:00 h) secretion profiles of GH and cortisol were determined in 10 healthy females (24.9±2.4 years, body mass index: 21.2±1.1) twice, receiving four boluses of 50 μg ghrelin or placebo at 22:00, 23:00, 00:00, and 01:00 h, in this single-blind, randomized, cross-over study. No significant differences of conventionally or quantitatively analyzed sleep were observed between ghrelin and placebo condition. First administration of ghrelin caused a marked mean increase of GH by 53.3 to 64.4±14.2 ng/ml (placebo: 5.9±1.5 ng/ml) and cortisol by 54.2 to 96.4±15.3 ng/ml (placebo: 27.5±4.7 ng/ml). The following ghrelin injections were associated with smaller increases of GH and cortisol. In the ghrelin condition, GH plasma levels remained significantly ( P
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2007.09.001