Direct observation therapy-highly active antiretroviral therapy in a resource-limited setting: the use of community treatment support can be effective

This study examines the use of various direct observation therapy-HAART treatment support modalities in Jos, Nigeria. A 12-month observational study enrolling 175 antiretroviral naïve patients into four arms of direct observation therapy-HAART (highly active antiretroviral therapy); daily observed t...

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Bibliographic Details
Published in:International journal of STD & AIDS 2007-11, Vol.18 (11), p.760-763
Main Authors: IDOKO, J. A, AGBAJI, O, IMADE, G, SANKALE, J. Louis, KANKI, Phyllis, AGABA, P, AKOLO, C, INUWA, B, HASSAN, Zuweira, AKINTUNDE, L, BADUNG, B, MUAZU, M, DANANG, M
Format: Article
Language:English
Subjects:
Adult
Aged
AIDS/HIV
Anti-HIV Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral Therapy, Highly Active
Antiviral agents
Biological and medical sciences
CD4 Lymphocyte Count
Directly Observed Therapy - methods
Epidemiology. Vaccinations
Female
General aspects
HIV Infections - drug therapy
HIV-1 - genetics
HIV-1 - isolation & purification
Human immunodeficiency virus 1
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Middle Aged
Nigeria
Patient Compliance
Pharmacology. Drug treatments
RNA, Viral - blood
Treatment Outcome
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral Load
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Summary:This study examines the use of various direct observation therapy-HAART treatment support modalities in Jos, Nigeria. A 12-month observational study enrolling 175 antiretroviral naïve patients into four arms of direct observation therapy-HAART (highly active antiretroviral therapy); daily observed therapy (DOT), twice weekly observed therapy (TWOT), weekly observed therapy (WOT) and self-administered therapy (SAT), examined community treatment support using family and community members. Treatment outcomes were much better in the treatment-supported groups compared with the control self-therapy group. CD4 cell increases were 218/μL (DOT), 267/μL (TWOT), 205/μL (WOT) versus 224/μL (SAT), whereas plasma HIV-1 RNA reached undetectable levels (
ISSN:0956-4624
1758-1052
DOI:10.1258/095646207782212252