Partial Response to Anti-CD20 Monoclonal Antibody Treatment of Severe Immune Thrombocytopenic Purpura in a Patient with Common Variable Immunodeficiency

• Published in: Annals of the New York Academy of Sciences 2005-06, Vol.1051 (1), p.666-671
• Main Authors: CARBONE, J., ESCUDERO, A., MAYAYO, M., BALLESTEROS, M., PEREZ-CORRAL, A., SANCHEZ-RAMON, S., SARMIENTO, E., MICHELOUD, D., FERNANDEZ-CRUZ, E.
• Format: Article
• Language: English
• Subjects: Adult; anti-CD20; Antibodies, Monoclonal - therapeutic use; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20 - immunology; common variable immunodeficiency; Common Variable Immunodeficiency - complications; Humans; immune thrombocytopenic purpura; Male; Purpura, Thrombocytopenic, Idiopathic - drug therapy; Rituximab
• ISSN: 0077-8923; 1749-6632
• DOI: 10.1196/annals.1361.111

: Immune thrombocytopenic purpura (ITP), alone or in combination with autoimmune hemolytic anemia (Evans syndrome) and/or autoimmune neutropenia, is frequent in patients with common variable immunodeficiency (CVID). A 34‐year‐old man with CVID had long‐standing unresponsive ITP. The patient had a 9‐year history of CVID on substitutive therapy with intravenous immunoglobulin (IVIG). The clinical course of CVID was complicated with refractory fistulizing inflammatory bowel disease, nodular regenerative hyperplasia of the liver, splenomegaly, severe portal hypertension, and hypercatabolism of IgG. ITP was refractory to medical therapy, including different combinations of corticosteroids, high‐dose IVIG, azathioprine, and vincristine. Splenectomy was not performed because of severe portal hypertension. He received a total five doses of rituximab, a monoclonal antibody directed against CD20 antigen, at a dose of 375 mg/m2. After an initially slow response, his platelet count increased to more than 50,000/μL by the fourth week of infusion. Therapy was well tolerated, and B lymphocytes were effectively depleted from the peripheral blood. The patient was completely tapered off glucocorticoids and maintained platelets at above 40,000/μL. The patient has not taken immunosuppressive agents for 11 months. Early treatment with rituximab might be an option for patients with CVID and ITP that do not respond to other treatments or for patients for whom a splenectomy is contraindicated.