Obesity: The role of hypothalamic AMP-activated protein kinase in body weight regulation

Obesity is rapidly increasing and is of great public health concern worldwide. Although there have been remarkable developments in obesity research over the past 10 years, the molecular mechanism of obesity is still not completely understood. Body weight results from the balance between food intake...

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Published in:The international journal of biochemistry & cell biology 2005-11, Vol.37 (11), p.2254-2259
Main Authors: Lee, Woo Je, Koh, Eun Hee, Won, Jong Chul, Kim, Min-Seon, Park, Joong-Yeol, Lee, Ki-Up
Format: Article
Language:English
Subjects:
Adipose Tissue - metabolism
Alpha-lipoic acid
AMP-Activated Protein Kinases
AMPK
Body Weight
Eating
Energy Metabolism
Homeostasis
Hypothalamus
Hypothalamus - metabolism
Multienzyme Complexes - metabolism
Obesity
Obesity - genetics
Obesity - metabolism
Obesity - physiopathology
Protein-Serine-Threonine Kinases - metabolism
Signal Transduction - physiology
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Summary:Obesity is rapidly increasing and is of great public health concern worldwide. Although there have been remarkable developments in obesity research over the past 10 years, the molecular mechanism of obesity is still not completely understood. Body weight results from the balance between food intake and energy expenditure. Recent studies have found that hypothalamic AMP-activated protein kinase plays a key role in regulating these processes. Leptin, insulin, glucose and alpha-lipoic acid have been shown to reduce food intake by lowering hypothalamic AMP-activated protein kinase activity, whereas ghrelin and glucose depletion increase food intake by increasing hypothalamic AMP-activated protein kinase activity. In addition, this enzyme plays a role in the central regulation of energy expenditure. These findings indicate that hypothalamic AMP-activated protein kinase is an important signal molecule, which integrates nutritional and hormonal signals and modulates feeding behavior and energy expenditure.
ISSN:1357-2725
1878-5875
DOI:10.1016/j.biocel.2005.06.019