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Sex reversal syndrome (64,XY; SRY-positive) in a mare demonstrating masculine behaviour
Summary A 5‐year‐old Thoroughbred mare was subjected to cytogenetic and molecular analysis because of infertility and masculine behaviour. Chromosome studies, including painting with the whole X chromosome specific probe, revealed a male chromosome complement (64,XY). The PCR amplification of the SR...
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| Published in: | Journal of animal breeding and genetics (1986) 2005-04, Vol.122 (s1), p.60-63 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4620-6e1a192d51c5aadefe431135e65855b6a6aab80da2512ede1eee22c8232656d63 |
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| cites | cdi_FETCH-LOGICAL-c4620-6e1a192d51c5aadefe431135e65855b6a6aab80da2512ede1eee22c8232656d63 |
| container_end_page | 63 |
| container_issue | s1 |
| container_start_page | 60 |
| container_title | Journal of animal breeding and genetics (1986) |
| container_volume | 122 |
| creator | Switonski, M. Chmurzynska, A. Szczerbal, I. Lipczynski, A. Yang, F. Nowicka-Posłuszna, A. |
| description | Summary
A 5‐year‐old Thoroughbred mare was subjected to cytogenetic and molecular analysis because of infertility and masculine behaviour. Chromosome studies, including painting with the whole X chromosome specific probe, revealed a male chromosome complement (64,XY). The PCR amplification of the SRY and ZFY genes showed the presence of both those genes, while the endocrinological study demonstrated a high level of testosterone (9.7 nmol/l). Sequencing of the SRY gene (1121 bp), comprising also 5′‐ and 3′‐UTRs, did not reveal any differences when compared with the sequence of normal stallions. It was proposed that this mare represents the androgen insensitivity syndrome (testicular feminization syndrome). |
| doi_str_mv | 10.1111/j.1439-0388.2005.00510.x |
| format | article |
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A 5‐year‐old Thoroughbred mare was subjected to cytogenetic and molecular analysis because of infertility and masculine behaviour. Chromosome studies, including painting with the whole X chromosome specific probe, revealed a male chromosome complement (64,XY). The PCR amplification of the SRY and ZFY genes showed the presence of both those genes, while the endocrinological study demonstrated a high level of testosterone (9.7 nmol/l). Sequencing of the SRY gene (1121 bp), comprising also 5′‐ and 3′‐UTRs, did not reveal any differences when compared with the sequence of normal stallions. It was proposed that this mare represents the androgen insensitivity syndrome (testicular feminization syndrome).</description><identifier>ISSN: 0931-2668</identifier><identifier>EISSN: 1439-0388</identifier><identifier>DOI: 10.1111/j.1439-0388.2005.00510.x</identifier><identifier>PMID: 16130458</identifier><language>eng</language><publisher>Berlin, Germany: Blackwell Verlag GmbH</publisher><subject>Androgens ; Animal behavior ; Animals ; Chromosome Aberrations - veterinary ; Chromosome Disorders - genetics ; Chromosome Disorders - veterinary ; Chromosomes ; Cytogenetic Analysis - veterinary ; Equus caballus ; Female ; Gender ; Genes ; Genes, sry - genetics ; Genitalia, Female - abnormalities ; Horse Diseases - blood ; Horse Diseases - genetics ; Horses ; Sequence Analysis, DNA - veterinary ; Sexual Behavior, Animal - physiology ; Testosterone - blood ; X Chromosome - genetics</subject><ispartof>Journal of animal breeding and genetics (1986), 2005-04, Vol.122 (s1), p.60-63</ispartof><rights>2005 Blackwell Verlag, Berlin</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4620-6e1a192d51c5aadefe431135e65855b6a6aab80da2512ede1eee22c8232656d63</citedby><cites>FETCH-LOGICAL-c4620-6e1a192d51c5aadefe431135e65855b6a6aab80da2512ede1eee22c8232656d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16130458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Switonski, M.</creatorcontrib><creatorcontrib>Chmurzynska, A.</creatorcontrib><creatorcontrib>Szczerbal, I.</creatorcontrib><creatorcontrib>Lipczynski, A.</creatorcontrib><creatorcontrib>Yang, F.</creatorcontrib><creatorcontrib>Nowicka-Posłuszna, A.</creatorcontrib><title>Sex reversal syndrome (64,XY; SRY-positive) in a mare demonstrating masculine behaviour</title><title>Journal of animal breeding and genetics (1986)</title><addtitle>J Anim Breed Genet</addtitle><description>Summary
A 5‐year‐old Thoroughbred mare was subjected to cytogenetic and molecular analysis because of infertility and masculine behaviour. Chromosome studies, including painting with the whole X chromosome specific probe, revealed a male chromosome complement (64,XY). The PCR amplification of the SRY and ZFY genes showed the presence of both those genes, while the endocrinological study demonstrated a high level of testosterone (9.7 nmol/l). Sequencing of the SRY gene (1121 bp), comprising also 5′‐ and 3′‐UTRs, did not reveal any differences when compared with the sequence of normal stallions. It was proposed that this mare represents the androgen insensitivity syndrome (testicular feminization syndrome).</description><subject>Androgens</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Chromosome Aberrations - veterinary</subject><subject>Chromosome Disorders - genetics</subject><subject>Chromosome Disorders - veterinary</subject><subject>Chromosomes</subject><subject>Cytogenetic Analysis - veterinary</subject><subject>Equus caballus</subject><subject>Female</subject><subject>Gender</subject><subject>Genes</subject><subject>Genes, sry - genetics</subject><subject>Genitalia, Female - abnormalities</subject><subject>Horse Diseases - blood</subject><subject>Horse Diseases - genetics</subject><subject>Horses</subject><subject>Sequence Analysis, DNA - veterinary</subject><subject>Sexual Behavior, Animal - physiology</subject><subject>Testosterone - blood</subject><subject>X Chromosome - genetics</subject><issn>0931-2668</issn><issn>1439-0388</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNkVtvEzEQhS1E1YbSv4AsHlCRusGXtder9qX0EkBRkVpQ6NPI2Z2A070EezdN_j0OiYrEC1iyPJr5zpHGhxDK2ZDH824-5KnMEyaNGQrG1DDeOFs9I4OnwXMyYLnkidDaHJAXIcwZi_0s3ycHXHPJUmUGZHKHK-pxiT7YioZ1U_q2Rnqs05Nv96f07vY-WbTBdW6Jb6lrqKW19UhLrNsmdN52rvkeW6HoK9cgneIPu3Rt71-SvZmtAh7t3kPy9frqy8WHZPx59PHifJwUqRYs0cgtz0WpeKGsLXGGqeRcKtTKKDXVVls7Nay0QnGBJXJEFKIwQgqtdKnlIXmz9V349mePoYPahQKryjbY9gG0USJXTPwT5FmaS2FkBF__Bc7jPk1cAoRknGVaqwiZLVT4NgSPM1h4F39mDZzBJiKYwyYJ2CQBm4jgd0SwitJXO_9-WmP5R7jLJAJnW-DRVbj-b2P49H4UiyhPtnIXOlw9ya1_AJ3JTMHkZgQsvZ2ML9MbUPIXvB-siA</recordid><startdate>200504</startdate><enddate>200504</enddate><creator>Switonski, M.</creator><creator>Chmurzynska, A.</creator><creator>Szczerbal, I.</creator><creator>Lipczynski, A.</creator><creator>Yang, F.</creator><creator>Nowicka-Posłuszna, A.</creator><general>Blackwell Verlag GmbH</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200504</creationdate><title>Sex reversal syndrome (64,XY; SRY-positive) in a mare demonstrating masculine behaviour</title><author>Switonski, M. ; Chmurzynska, A. ; Szczerbal, I. ; Lipczynski, A. ; Yang, F. ; Nowicka-Posłuszna, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4620-6e1a192d51c5aadefe431135e65855b6a6aab80da2512ede1eee22c8232656d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Androgens</topic><topic>Animal behavior</topic><topic>Animals</topic><topic>Chromosome Aberrations - veterinary</topic><topic>Chromosome Disorders - genetics</topic><topic>Chromosome Disorders - veterinary</topic><topic>Chromosomes</topic><topic>Cytogenetic Analysis - veterinary</topic><topic>Equus caballus</topic><topic>Female</topic><topic>Gender</topic><topic>Genes</topic><topic>Genes, sry - genetics</topic><topic>Genitalia, Female - abnormalities</topic><topic>Horse Diseases - blood</topic><topic>Horse Diseases - genetics</topic><topic>Horses</topic><topic>Sequence Analysis, DNA - veterinary</topic><topic>Sexual Behavior, Animal - physiology</topic><topic>Testosterone - blood</topic><topic>X Chromosome - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Switonski, M.</creatorcontrib><creatorcontrib>Chmurzynska, A.</creatorcontrib><creatorcontrib>Szczerbal, I.</creatorcontrib><creatorcontrib>Lipczynski, A.</creatorcontrib><creatorcontrib>Yang, F.</creatorcontrib><creatorcontrib>Nowicka-Posłuszna, A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of animal breeding and genetics (1986)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Switonski, M.</au><au>Chmurzynska, A.</au><au>Szczerbal, I.</au><au>Lipczynski, A.</au><au>Yang, F.</au><au>Nowicka-Posłuszna, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex reversal syndrome (64,XY; SRY-positive) in a mare demonstrating masculine behaviour</atitle><jtitle>Journal of animal breeding and genetics (1986)</jtitle><addtitle>J Anim Breed Genet</addtitle><date>2005-04</date><risdate>2005</risdate><volume>122</volume><issue>s1</issue><spage>60</spage><epage>63</epage><pages>60-63</pages><issn>0931-2668</issn><eissn>1439-0388</eissn><abstract>Summary
A 5‐year‐old Thoroughbred mare was subjected to cytogenetic and molecular analysis because of infertility and masculine behaviour. Chromosome studies, including painting with the whole X chromosome specific probe, revealed a male chromosome complement (64,XY). The PCR amplification of the SRY and ZFY genes showed the presence of both those genes, while the endocrinological study demonstrated a high level of testosterone (9.7 nmol/l). Sequencing of the SRY gene (1121 bp), comprising also 5′‐ and 3′‐UTRs, did not reveal any differences when compared with the sequence of normal stallions. It was proposed that this mare represents the androgen insensitivity syndrome (testicular feminization syndrome).</abstract><cop>Berlin, Germany</cop><pub>Blackwell Verlag GmbH</pub><pmid>16130458</pmid><doi>10.1111/j.1439-0388.2005.00510.x</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0931-2668 |
| ispartof | Journal of animal breeding and genetics (1986), 2005-04, Vol.122 (s1), p.60-63 |
| issn | 0931-2668 1439-0388 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68529502 |
| source | Wiley |
| subjects | Androgens Animal behavior Animals Chromosome Aberrations - veterinary Chromosome Disorders - genetics Chromosome Disorders - veterinary Chromosomes Cytogenetic Analysis - veterinary Equus caballus Female Gender Genes Genes, sry - genetics Genitalia, Female - abnormalities Horse Diseases - blood Horse Diseases - genetics Horses Sequence Analysis, DNA - veterinary Sexual Behavior, Animal - physiology Testosterone - blood X Chromosome - genetics |
| title | Sex reversal syndrome (64,XY; SRY-positive) in a mare demonstrating masculine behaviour |
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