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Evolution of Subclinical Hypothyroidism in Children Treated With Antiepileptic Drugs

The concentration levels of serum free thyroxine, serum free triiodothyronine, and thyroid-stimulating hormone were measured in 20 children receiving carbamazepine, 32 children receiving valproic acid, and 5 children receiving phenobarbital at the following times: (1) during chronic treatment, and (...

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Published in:Pediatric neurology 2007-12, Vol.37 (6), p.426-430
Main Authors: Castro-Gago, Manuel, MD, Novo-Rodríguez, María Inés, MD, Gómez-Lado, Carmen, MD, Rodríguez-García, Javier, PhD, Rodríguez-Segade, Santiago, PhD, Eirís-Puñal, Jesús, MD
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Language:English
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Summary:The concentration levels of serum free thyroxine, serum free triiodothyronine, and thyroid-stimulating hormone were measured in 20 children receiving carbamazepine, 32 children receiving valproic acid, and 5 children receiving phenobarbital at the following times: (1) during chronic treatment, and (2) 3 months after the end of treatment with antiepileptic drugs. Patients during chronic treatment revealed significant changes in serum thyroid hormones, especially the children treated with carbamazepine and valproic acid. A number of children receiving long-term therapy with the two last antiepileptic drugs had varying grades of subclinical hypothyroidism. Three months after the end of treatment, a complete return to normal of all parameters was observed. These data demonstrate that the changes induced by these drugs are transient and reversible.
ISSN:0887-8994
1873-5150
DOI:10.1016/j.pediatrneurol.2007.07.003