New trends in the treatment of bone metastasis

Bone metastasis is often the penultimate harbinger of death for many cancer patients. Bone metastases are often associated with fractures and severe pain resulting in decreased quality of life. Accordingly, effective therapies to inhibit the development or progression of bone metastases will have im...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2007-12, Vol.102 (5), p.1095-1102
Main Authors: Keller, Evan T., Dai, Jinlu, Escara-Wilke, June, Hall, Christopher L., Ignatoski, Kathleen, Taichman, Russell S., Keller, Jill
Format: Article
Language:English
Subjects:
Antineoplastic Agents - therapeutic use
BMP
Bone Neoplasms - drug therapy
Bone Neoplasms - pathology
Bone Neoplasms - secondary
breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
CXCR4
Diphosphonates - therapeutic use
Female
Humans
Male
Neoplasm Metastasis - drug therapy
Neoplasm Metastasis - pathology
Osteolysis - therapy
Osteoprotegerin - metabolism
prostate cancer
Prostatic Neoplasms - drug therapy
PTHrP
RANK Ligand - metabolism
RANKL
SDF
Wnt
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Summary:Bone metastasis is often the penultimate harbinger of death for many cancer patients. Bone metastases are often associated with fractures and severe pain resulting in decreased quality of life. Accordingly, effective therapies to inhibit the development or progression of bone metastases will have important clinical benefits. To achieve this goal understanding the mechanisms through which bone metastases develop and progress may provide targets to inhibit the metastases. In the past few years, there have been advances in both understanding the mechanisms through which bone metastases develop and how they impact bone remodeling. Additionally, gains in promising clinical strategies to target bone metastases have been developed. In this prospectus, we will discuss some of these advances. J. Cell. Biochem. 102: 1095–1102, 2007. © 2007 Wiley‐Liss, Inc.
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.21540