Clinical Significance of Ghrelin Concentration of Plasma and Tumor Tissue in Patients with Gastric Cancer

Background The nutritional status of gastric cancer patients is an important factor determining the outcome after a gastrectomy. Ghrelin is produced primarily in the gastrointestinal tract including the stomach, and has been reported to reflect the nutritional status and control homeostasis by influ...

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Bibliographic Details
Published in:The Journal of surgical research 2007-12, Vol.143 (2), p.344-349
Main Authors: An, Ji Yeong, M.D, Choi, Min-Gew, M.D, Noh, Jae Hyung, M.D, Sohn, Tae Sung, M.D, Jin, Dong-Kyu, M.D, Kim, Sung, M.D
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - secondary
Adenocarcinoma - surgery
Adenocarcinoma, Mucinous - metabolism
Adenocarcinoma, Mucinous - secondary
Adenocarcinoma, Mucinous - surgery
Adult
Aged
Biological and medical sciences
Carcinoma, Signet Ring Cell - metabolism
Carcinoma, Signet Ring Cell - secondary
Carcinoma, Signet Ring Cell - surgery
Female
Gastrectomy
Gastric Mucosa - metabolism
General aspects
ghrelin
Ghrelin - blood
Helicobacter Infections - pathology
Helicobacter pylori
Humans
Lymphatic Metastasis
Male
Medical sciences
Middle Aged
neoplasms
Nutrition Assessment
stomach
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Stomach, duodenum, intestine, rectum, anus
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Weight Loss
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Summary:Background The nutritional status of gastric cancer patients is an important factor determining the outcome after a gastrectomy. Ghrelin is produced primarily in the gastrointestinal tract including the stomach, and has been reported to reflect the nutritional status and control homeostasis by influencing the level of food intake and adiposity. This study examined the difference in the plasma and tissue ghrelin levels according to the clinicopathological features and the extent of a gastric resection in gastric cancer patients who underwent a gastrectomy. Patients and methods Eighty patients over a 3 mo-period were divided into two groups according to the degree of preoperative weight loss (weight loss ≥5% or
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2007.02.017