Polymorphisms of myelin-associated glycoprotein gene are associated with schizophrenia in the Chinese Han population

Results of gene expression microarray and quantitative PCR studies have suggested abnormalities in the expression of myelin-related genes including myelin-associated glycoprotein ( MAG) in schizophrenic patients. Research provides strong evidence for oligodendrocyte dysfunction in schizophrenics. In...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience letters 2005-11, Vol.388 (3), p.126-131
Main Authors: Wan, Chunling, Yang, Yifeng, Feng, Guoyin, Gu, Niufan, Liu, Huijun, Zhu, Shaomin, He, Lin, Wang, Li
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Association study
Biological and medical sciences
Brain - metabolism
Brain - physiopathology
Brain Chemistry - genetics
Case-Control Studies
China - epidemiology
DNA Mutational Analysis
Female
Genetic Predisposition to Disease - genetics
Genetic Testing
Haplotypes - genetics
Humans
Male
Medical sciences
Myelin-associated glycoprotein
Myelin-Associated Glycoprotein - genetics
Polymorphism, Genetic - genetics
Polymorphism, Single Nucleotide - genetics
Polymorphisms
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - ethnology
Schizophrenia - genetics
Schizophrenia - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Results of gene expression microarray and quantitative PCR studies have suggested abnormalities in the expression of myelin-related genes including myelin-associated glycoprotein ( MAG) in schizophrenic patients. Research provides strong evidence for oligodendrocyte dysfunction in schizophrenics. In order to further assess the role of MAG in schizophrenia, we examined four single nucleotide polymorphisms (SNPs), namely rs2301600, rs3746248, rs720309 and rs720308, of this gene in Chinese schizophrenic patients ( n = 470) and healthy controls ( n = 470). The distribution of rs720309 T/A genotypes showed a strong association with schizophrenia ( χ 2 = 14.58, d.f. = 2, P = 0.0008). A haplotype constructed of rs720309–rs720308 also revealed a significant association with schizophrenia ( χ 2 = 11.914, d.f. = 3, P = 0.0084). Our findings of a significant associations between schizophrenia and the MAG gene suggest that this gene may be involved in susceptibility to schizophrenia in the Chinese Han population.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2005.06.051