Preeclampsia: At Risk for Remote Cardiovascular Disease

Epidemiological data indicate that women with preeclampsia are more likely to develop cardiovascular disease (CVD) later in life. Population-based studies relate preeclampsia to an increased risk of later chronic hypertension (RR, 2.00 to 8.00) and cardiovascular morbidity/mortality (RR, 1.3 to 3.07...

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Bibliographic Details
Published in:The American journal of the medical sciences 2007-10, Vol.334 (4), p.291-295
Main Authors: Harskamp, Ralf E., Zeeman, Gerda G.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiovascular disease
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - physiopathology
Diseases of mother, fetus and pregnancy
Female
General aspects
Gynecology. Andrology. Obstetrics
Humans
Hypertension
Hypertension - epidemiology
Hypertension - physiopathology
Medical sciences
Metabolic syndrome
Metabolic Syndrome - complications
Metabolic Syndrome - physiopathology
Pre-Eclampsia - diagnosis
Pre-Eclampsia - physiopathology
Preeclampsia
Pregnancy
Pregnancy. Fetus. Placenta
Risk Factors
Stroke - epidemiology
Stroke - physiopathology
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Summary:Epidemiological data indicate that women with preeclampsia are more likely to develop cardiovascular disease (CVD) later in life. Population-based studies relate preeclampsia to an increased risk of later chronic hypertension (RR, 2.00 to 8.00) and cardiovascular morbidity/mortality (RR, 1.3 to 3.07), compared with normotensive pregnancy. Women who develop preeclampsia before 36 weeks of gestation or have multiple hypertensive pregnancies are at highest risk (RR, 3.4 to 8.12). The underlying mechanism for the remote effects of preeclampsia is complex and probably multifactorial. Many risk factors are shared by CVD and preeclampsia, including endothelial dysfunction, obesity, hypertension, hyperglycemia, insulin resistance, and dyslipidemia. Therefore, it has been proposed that the metabolic syndrome may be a possible underlying mechanism common to CVD and preeclampsia. Follow-up and counseling of women with a history of preeclampsia may offer a window of opportunity for prevention of future disease.
ISSN:0002-9629
1538-2990
DOI:10.1097/MAJ.0b013e3180a6f094