Asthma in medium altitude – exercise‐induced bronchoconstriction in hypobaric environment in subjects with asthma

Background:  Hypoxic gas inhalation has been reported to enhance airway responsiveness and results in bronchoconstriction in animal models and in humans with asthma. However, the data have so far been conflicting. The aim of the present study was to examine the effect of reduced barometric pressure...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2005-10, Vol.60 (10), p.1308-1311
Main Authors: Berntsen, S., Stensrud, T., Ingjer, F., Vilberg, A., Carlsen, K.‐H.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Allergic diseases
Altitude
asthma
Asthma, Exercise-Induced - physiopathology
Biological and medical sciences
Bronchoconstriction - physiology
Child
Cross-Over Studies
Exercise - physiology
exercise‐induced bronchoconstriction
Forced Expiratory Volume
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Heart Rate
Humans
hypobaric environment
Immunopathology
lung function
Maximal Midexpiratory Flow Rate
Medical sciences
Middle Aged
Oxygen - blood
oxygen saturation
oxygen uptake
Pulmonary Ventilation
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Summary:Background:  Hypoxic gas inhalation has been reported to enhance airway responsiveness and results in bronchoconstriction in animal models and in humans with asthma. However, the data have so far been conflicting. The aim of the present study was to examine the effect of reduced barometric pressure on exercise‐induced bronchoconstriction (EIB) in subjects with asthma. Methods:  Twenty subjects (10–45 years old, ♂/♀ = 13/7) with asthma (at least 10% reduction in forced expiratory volume in 1‐second postexercise) participated in exercise testing in barometric pressure corresponding to altitudes of 200 (normobaric) and 2500 (hypobaric) m above sea level in random order on separate days. Lung function was measured before and after exercise, as well as after inhalation of salbutamol. Heart rate, oxygen uptake (), arterial oxygen saturation (SpO2), respiratory gas exchange ratio (RER) and minute ventilation () were measured during exercise. Results:  There was no difference in lung function after exercise. The and HRpeak during exercise did not differ. The RERpeak was higher (P = 0.04) in hypobaric environment. The decreased 10.1% (7.2–13.0) [mean (95% confidence intervals)] (P 
ISSN:0105-4538
1398-9995
DOI:10.1111/j.1398-9995.2005.00914.x