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Brain aging phenomena in migrating sockeye salmon Oncorhynchus nerka nerka

Aging, a process occurring in all vertebrates, is closely related to a loss in physical and functional abilities. There is widespread interest in clarifying the relevance of environmental, metabolic, and genetic factors for vertebrate aging. In the Pacific salmon a dramatic example of aging is known...

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Published in:Journal of Neural Transmission 2005-09, Vol.112 (9), p.1177-1199
Main Authors: Götz, M E, Malz, C R, Dirr, A, Blum, D, Gsell, W, Schmidt, S, Burger, R, Pohli, S, Riederer, P
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cited_by cdi_FETCH-LOGICAL-c357t-8818aa2d0d102d850244bfbe62076f737ab657773ceda7524c7e43f4ebfed7dc3
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container_issue 9
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container_title Journal of Neural Transmission
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creator Götz, M E
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Riederer, P
description Aging, a process occurring in all vertebrates, is closely related to a loss in physical and functional abilities. There is widespread interest in clarifying the relevance of environmental, metabolic, and genetic factors for vertebrate aging. In the Pacific salmon a dramatic example of aging is known. Looking for changes in the salmon brain, perhaps even in the role of initiating the aging processes, we investigated several biochemical parameters that should reflect brain functional activity and stress response such as the neurotransmitters dopamine, and serotonin, and two of their respective metabolites 3,4-dihydroxyphenylacetic acid, and 5-hydroxyindole acetic acid, as well as glutathione, glutathione disulfide, and the extent of terminal deoxynucleotidyltransferase-mediated dUTP nick end-labelling. The aging of migrating sockeye salmon (Oncorhynchus nerka nerka) is accompanied by gradual increase in dopamine and serotonin turnover and a gradual decrease of brain total protein and glutathione levels. There appears to be an increased need for detoxification of reactive biological intermediates since activities of superoxide dismutase and catalase increase with age. However, our data do not support a major increase in apoptotic cell death during late aging but rather implicate an age related downward regulation of protein and glutathione synthesis and proteolysis increasing the need for autophagocytosis or heterophagocytosis in the course of cell death.
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subjects 3,4-Dihydroxyphenylacetic Acid - metabolism
Aging - physiology
Animal Migration - physiology
Animals
Antioxidants - metabolism
Apoptosis - physiology
Brain - cytology
Brain - metabolism
Catalase - metabolism
Dopamine - metabolism
Female
Glutathione - metabolism
Glutathione Disulfide - metabolism
Homovanillic Acid - metabolism
Hydroxyindoleacetic Acid - metabolism
Nerve Degeneration
Neurotransmitter Agents - metabolism
Oncorhynchus nerka
Salmon - physiology
Serotonin - metabolism
Superoxide Dismutase - metabolism
title Brain aging phenomena in migrating sockeye salmon Oncorhynchus nerka nerka
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