Pulmonary involvement in rheumatoid arthritis

The primary objective of this investigation was to assess the relationships between clinical characteristics, lung involvement, and frequency of pulmonary involvement in rheumatoid arthritis (RA). Using high-resolution computed tomography (HRCT) and pulmonary function tests (PFT), we prospectively e...

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Bibliographic Details
Published in:Rheumatology international 2005-09, Vol.25 (6), p.429-435
Main Authors: BILGICI, Ayhan, ULUSOY, H, KURU, O, CELENK, C, UNSAL, M, DANACI, M
Format: Article
Language:English
Subjects:
Adult
Aged
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - pathology
Arthritis, Rheumatoid - physiopathology
Biological and medical sciences
Diseases of the osteoarticular system
Drug therapy
Female
Humans
Inflammatory joint diseases
Lung Diseases - etiology
Lung Diseases - pathology
Lung Diseases - physiopathology
Male
Medical sciences
Middle Aged
Pneumology
Prospective Studies
Radiography, Thoracic
Respiratory Function Tests
Respiratory system : syndromes and miscellaneous diseases
Rheumatoid arthritis
Tomography, X-Ray Computed
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Summary:The primary objective of this investigation was to assess the relationships between clinical characteristics, lung involvement, and frequency of pulmonary involvement in rheumatoid arthritis (RA). Using high-resolution computed tomography (HRCT) and pulmonary function tests (PFT), we prospectively evaluated 52 patients with RA (eight males and 44 females, mean age 53.6 years). The HRCT was abnormal in 35 patients (67.3%), the most frequent abnormalities being reticulonodular patterns, which were found in 22 patients (62.9%), ground-glass attenuation (20%), and bronchiectasis (17%). In this group of patients, PFT results were normal in 13 patients (37%). Titers of rheumatoid factor and erythrocyte sedimentation rate were significantly higher in abnormal HRCT presence. Higher Larsen's score, advanced age, and severe disease were significant risk factors for lung involvement (p
ISSN:0172-8172
1437-160X
DOI:10.1007/s00296-004-0472-y