Divergent Selection for Ascites Incidence in Chickens

• Published in: Poultry science 2007-12, Vol.86 (12), p.2517-2529
• Main Authors: Pavlidis, H.O, Balog, J.M, Stamps, L.K, Hughes, J.D. Jr, Huff, W.E, Anthony, N.B
• Format: Article
• Language: English
• Subjects: Altitude; animal genetic resources; Animals; artificial selection; ascites; Ascites - genetics; Ascites - mortality; Ascites - veterinary; Body Weight; broiler chickens; Chickens - genetics; disease incidence; disease resistance; divergent selection; genetic correlation; Genetic Predisposition to Disease; Heart; heart ventricle; heritability; hypobaric chambers; Hypoxia - veterinary; Inbreeding; Incidence; livability; mortality; oxygen; partial pressure; Poultry Diseases - genetics; Pressure; selection response; Selection, Genetic
• ISSN: 0032-5791; 1525-3171
• DOI: 10.3382/ps.2007-00134

Chicken lines that were either resistant or susceptible to ascites syndrome were developed by using a hypobaric chamber to induce the disease. Birds were reared in a hypobaric chamber that simulated high altitude by operating under a partial vacuum, which thereby lowered the partial pressure of oxygen. Ascites mortality data from birds reared under hypobaric chamber conditions were used to select siblings to be used for breeding. The response to selection for the susceptible (SUS) and resistant (RES) lines of chickens was very rapid from the base population, which exhibited an incidence of ascites of 75.3%. Extremes in the incidence of ascites were observed in generation 8, with line SUS exhibited an average incidence of ascites of 95.1%, and in generation 9, with line RES exhibited an average incidence of ascites of 7.1%. The incidence of ascites in the relaxed line remained relatively stable and currently has a general incidence of ascites of 60%. The heritability estimates ± SE for ascites were estimated to be 0.30 ± 0.05 and 0.55 ± 0.05 for lines SUS and RES, respectively. Changes in the incidence of ascites appeared to be associated with livability. By generation 10, selection for ascites in line RES increased livability by 11.5 d, whereas in line SUS, livability was decreased by 8 d. Although divergent selection for ascites resulted in a reduction in d 42 BW for both the SUS and RES lines, the SUS line was approximately 163 g heavier than the RES line. Negative genetic correlations between ascites and the right ventricle:total ventricle (RV:TV) ratio were observed in both the SUS and RES lines; however, no significant change in the RV:TV ratio was observed for birds reared under normal conditions in either line. The current data raise questions about the validity of using the RV:TV ratio as an indicator trait in a selection program designed to reduce the incidence of ascites. Overall, direct selection for resistance to ascites by using sire family performance appeared to be an effective means of reducing the incidence of ascites. However, simultaneous selection for BW should be applied to counterbalance the losses in correlated BW.