The Brain is Hyperexcitable in Migraine

Migraine is a very common disorder occurring in 20% of women and 6% of men. Central neuronal hyperexcitability is proposed to be the putative basis for the physiological disturbances in migraine. Since there are no consistent structural disturbances in migraine, physiological and psychophysical stud...

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Bibliographic Details
Published in:Cephalalgia 2007-12, Vol.27 (12), p.1442-1453
Main Authors: Aurora, SK, Wilkinson, F
Format: Article
Language:English
Subjects:
Cerebral Cortex - physiopathology
Evoked Potentials
Humans
Hyperalgesia - physiopathology
hyperexcitability
Migraine
Migraine Disorders - physiopathology
Models, Neurological
neurophysiology
psychophysics
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Summary:Migraine is a very common disorder occurring in 20% of women and 6% of men. Central neuronal hyperexcitability is proposed to be the putative basis for the physiological disturbances in migraine. Since there are no consistent structural disturbances in migraine, physiological and psychophysical studies have provided insight into the underlying mechanisms. This is a review of the neurophysiological studies which have provided an insight to migraine pathogenesis supporting the theory of hyperexcitability.
ISSN:0333-1024
1468-2982
DOI:10.1111/j.1468-2982.2007.01502.x