The significance of the intraoperative repeated dosing of antimicrobials for preventing surgical wound infection in colorectal surgery

It is widely accepted that antimicrobial prophylaxis is useful for the prevention of surgical wound infection, especially in colorectal surgery. While many reports support the finding that the first dose should be administered immediately before surgery, there is less evidence concerning the ideal t...

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Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 2005-09, Vol.35 (9), p.732-738
Main Authors: Morita, Shunji, Nishisho, Isamu, Nomura, Takashi, Fukushima, Yukio, Morimoto, Takashi, Hiraoka, Nobuaki, Shibata, Nobuhiro
Format: Article
Language:English
Subjects:
Aged
Antibiotic Prophylaxis - methods
Cefazolin - administration & dosage
Cefmetazole - administration & dosage
Cefotiam - administration & dosage
Cefozopran
Cephalosporins - administration & dosage
Colorectal Neoplasms - surgery
Female
Humans
Intraoperative Care
Logistic Models
Male
Middle Aged
Retrospective Studies
Risk Factors
Statistics, Nonparametric
Surgical Wound Infection - prevention & control
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Summary:It is widely accepted that antimicrobial prophylaxis is useful for the prevention of surgical wound infection, especially in colorectal surgery. While many reports support the finding that the first dose should be administered immediately before surgery, there is less evidence concerning the ideal timing for the second dose. The purpose of this study is to examine the significance of intraoperative repeated dosing. A surgical series of 131 patients with primary colorectal cancer was retrospectively analyzed for 14 parameters, including the protocols of antimicrobial administration to determine the clinical risk factors for surgical wound infection. The overall surgical wound infection rate of the 131 patients was 16.0% (21/131). When the operation finished within 4 h after the first dose (n = 29), wound infection was observed in only one patient (3.4%). In a prolonged operation exceeding 4 h after the first dose, the surgical wound infection rates were 8.5% and 26.5%, respectively, for those with (n = 47) and without (n = 49) intraoperative repeated dosing, which were significantly different based on both a univariate analysis (P = 0.031) and a multivariate analysis (P = 0.0079). Intraoperative repeated antimicrobial dosing is therefore recommended to prevent the surgical wound infection for prolonged colorectal surgery.
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-005-3026-3