Minor Sesquiterpene Lactones from Centaurea pullata and Their Antimicrobial Activity

The aerial parts of Centaurea pullata afforded, in addition to the previously isolated sesquiterpene lactones, 11β,13-dihydrocnicin and 11β,13-dihydro-19-desoxycnicin, three minor sesquiterpene lactones, namely, a new germacranolide, 8α-O-(4-acetoxy-5-hydroxyangeloyl)-11β,13-dihydrocnicin, and two n...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2007-11, Vol.70 (11), p.1796-1799
Main Authors: Djeddi, Samah, Karioti, Anastasia, Sokovic, Marina, Stojkovic, Dejan, Seridi, Ratiba, Skaltsa, Helen
Format: Article
Language:English
Subjects:
Algeria
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
antibacterial properties
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
antifungal properties
Bacteria - drug effects
Biological and medical sciences
Centaurea
Centaurea - chemistry
Centaurea pullata
chemical structure
dihydrocnicin
eudesmanolide
Fungi - drug effects
General pharmacology
germacranolide
human health
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Medical sciences
Microbial Sensitivity Tests
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
Sesquiterpenes, Germacrane - chemistry
Sesquiterpenes, Germacrane - isolation & purification
Sesquiterpenes, Germacrane - pharmacology
sesquiterpenoid lactones
spectral analysis
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Summary:The aerial parts of Centaurea pullata afforded, in addition to the previously isolated sesquiterpene lactones, 11β,13-dihydrocnicin and 11β,13-dihydro-19-desoxycnicin, three minor sesquiterpene lactones, namely, a new germacranolide, 8α-O-(4-acetoxy-5-hydroxyangeloyl)-11β,13-dihydrocnicin, and two new eudesmanolides, 8α-O-(4-hydroxy-2-methylenebutanoyloxy)-11β,13-dihydrosonchucarpolide and 8α-O-(4-hydroxy-2-methylenebutanoyloxy)-11β,13-dihydro-4-epi-sonchucarpolide. The in vitro antimicrobial activity of all isolated sesquiterpene lactones was tested against six bacteria and eight fungal species, using a microdilution method. All compounds tested showed greater antibacterial and antifungal activities than the positive controls used.
ISSN:0163-3864
1520-6025
DOI:10.1021/np070125i