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Genome-wide scan for adiposity-related phenotypes in adults from American Samoa
Objective: To detect quantitative trait loci influencing adiposity-related phenotypes assessed by body mass index (BMI), abdominal circumference (ABDCIR), percent body fat (%BFAT) and fasting serum leptin and adiponectin using a whole genome linkage scan of families from American Samoa. Design: Fami...
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| Published in: | International Journal of Obesity 2007-12, Vol.31 (12), p.1832-1842 |
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| Main Authors: | , , , , , , , , , , , |
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| Language: | English |
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| container_end_page | 1842 |
| container_issue | 12 |
| container_start_page | 1832 |
| container_title | International Journal of Obesity |
| container_volume | 31 |
| creator | Dai, F Keighley, E D Sun, G Indugula, S R Roberts, S T Åberg, K Smelser, D Tuitele, J Jin, L Deka, R Weeks, D E McGarvey, S T |
| description | Objective:
To detect quantitative trait loci influencing adiposity-related phenotypes assessed by body mass index (BMI), abdominal circumference (ABDCIR), percent body fat (%BFAT) and fasting serum leptin and adiponectin using a whole genome linkage scan of families from American Samoa.
Design:
Family-based linkage analysis, the probands and family members were unselected for obesity.
Subjects:
A total of 583 phenotyped American Samoan adults, of which 578 were genotyped in 34 pedigrees.
Measurements:
A total of 377 autosomal and 18 X chromosome microsatellite markers were typed at an approximate average spacing of 10 c
M
spanning the genome. Multipoint LOD (logarithm of the odds) scores were calculated using variance-components approaches and SOLAR/LOKI software. The covariates simultaneously evaluated were age, sex, education, farm work and cigarette smoking, with a significance level of 0.1. Due to the stochastic nature of LOKI, we report the average of maximum LOD scores from 10 runs.
Results:
Significant linkage to leptin was found at 6q32.2 with LOD of 3.83. Suggestive linkage to leptin was found at 16q21:LOD=2.98, 1q42.2:LOD=1.97, 5q11.2:LOD=2.08, 12q24.23:LOD=2.00, 19p13.3:LOD=2.05; adiponectin was linked to 13q33.1–q22.1:LOD=2.41; %BFAT was linked to 16q12.2–q21, LOD=2.24; ABDCIR was linked to 16q23.1:LOD=1.95; %BFAT-adjusted leptin to 14q12, LOD=2.01; %BFAT-adjusted ABDCIR to 1q31.1, LOD=2.36, to 3q27.3–q28, LOD=2.10 and to 12p12.3, LOD=2.04.
Conclusion:
We found strong evidence for a major locus on 6q23.2 influencing serum leptin levels in American Samoans. The 16q21 region appears to harbor a susceptibility locus that has significant pleiotrophic effects on phenotypes BMI, %BFAT, leptin and ABDCIR as shown by bivariate linkage analyses. Several other loci of varying significance were detected across the genome. |
| doi_str_mv | 10.1038/sj.ijo.0803675 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_68543316</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A190151305</galeid><sourcerecordid>A190151305</sourcerecordid><originalsourceid>FETCH-LOGICAL-c559t-c2ee8132bd4aeb90b0deb0bf127076654b39dfe6bc235cb707d2d0bd5c3a6d03</originalsourceid><addsrcrecordid>eNqFksGL1DAUxoso7rh69ShFcW-dfUmatDkOi67Cwh7ce0iT152UtqlJyzL_vRmmMCorkkPgvd_3PV7yZdl7AlsCrL6O3dZ1fgs1MFHxF9mGlJUoeCmrl9kGGFQFcMEvsjcxdgDAOdDX2QWpBCWM0E12f4ujH7B4chbzaPSYtz7k2rrJRzcfioC9ntHm0z5x82HCmLsx9Zd-jnkb_JDvBgzuKPyhB6_fZq9a3Ud8t96X2cPXLw8334q7-9vvN7u7wnAu58JQxJow2thSYyOhAYsNNC2hFVRC8LJh0rYoGkMZN00qWmqhsdwwLSywy-zqZDsF_3PBOKvBRYN9r0f0S1Si5iVjRPwXpAAEiKAJ_PgX2PkljGkHRYmkwKHiCfp0gh51j8qNrZ-DNkdHtSMSCCcMjtT2GSodi4MzfsTWpfofgqvfBHvU_byPvl9m58f4rLMJPsaArZqCG3Q4KALqmAcVO5XyoNY8JMGHdaulGdCe8TUACfi8Ajr9ft8GPRoXz5yshaRSJu76xMXUGh8xnJ_nH6N_AWg9y40</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219205075</pqid></control><display><type>article</type><title>Genome-wide scan for adiposity-related phenotypes in adults from American Samoa</title><source>Nature</source><creator>Dai, F ; Keighley, E D ; Sun, G ; Indugula, S R ; Roberts, S T ; Åberg, K ; Smelser, D ; Tuitele, J ; Jin, L ; Deka, R ; Weeks, D E ; McGarvey, S T</creator><creatorcontrib>Dai, F ; Keighley, E D ; Sun, G ; Indugula, S R ; Roberts, S T ; Åberg, K ; Smelser, D ; Tuitele, J ; Jin, L ; Deka, R ; Weeks, D E ; McGarvey, S T</creatorcontrib><description>Objective:
To detect quantitative trait loci influencing adiposity-related phenotypes assessed by body mass index (BMI), abdominal circumference (ABDCIR), percent body fat (%BFAT) and fasting serum leptin and adiponectin using a whole genome linkage scan of families from American Samoa.
Design:
Family-based linkage analysis, the probands and family members were unselected for obesity.
Subjects:
A total of 583 phenotyped American Samoan adults, of which 578 were genotyped in 34 pedigrees.
Measurements:
A total of 377 autosomal and 18 X chromosome microsatellite markers were typed at an approximate average spacing of 10 c
M
spanning the genome. Multipoint LOD (logarithm of the odds) scores were calculated using variance-components approaches and SOLAR/LOKI software. The covariates simultaneously evaluated were age, sex, education, farm work and cigarette smoking, with a significance level of 0.1. Due to the stochastic nature of LOKI, we report the average of maximum LOD scores from 10 runs.
Results:
Significant linkage to leptin was found at 6q32.2 with LOD of 3.83. Suggestive linkage to leptin was found at 16q21:LOD=2.98, 1q42.2:LOD=1.97, 5q11.2:LOD=2.08, 12q24.23:LOD=2.00, 19p13.3:LOD=2.05; adiponectin was linked to 13q33.1–q22.1:LOD=2.41; %BFAT was linked to 16q12.2–q21, LOD=2.24; ABDCIR was linked to 16q23.1:LOD=1.95; %BFAT-adjusted leptin to 14q12, LOD=2.01; %BFAT-adjusted ABDCIR to 1q31.1, LOD=2.36, to 3q27.3–q28, LOD=2.10 and to 12p12.3, LOD=2.04.
Conclusion:
We found strong evidence for a major locus on 6q23.2 influencing serum leptin levels in American Samoans. The 16q21 region appears to harbor a susceptibility locus that has significant pleiotrophic effects on phenotypes BMI, %BFAT, leptin and ABDCIR as shown by bivariate linkage analyses. Several other loci of varying significance were detected across the genome.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0803675</identifier><identifier>PMID: 17621312</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adipose tissues ; Adiposity - ethnology ; Adiposity - genetics ; Adult ; Adults ; American Samoa ; Biological and medical sciences ; Body fat ; Body Mass Index ; Chromosome Mapping ; Cigarettes ; Diabetes ; Education ; Epidemiology ; Families & family life ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gene mapping ; Genes ; Genetic aspects ; Genetic Linkage - genetics ; Genome, Human ; Genomes ; Genomics ; Health aspects ; Health Promotion and Disease Prevention ; Humans ; Internal Medicine ; Leptin ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Modernization ; Obesity ; Obesity - ethnology ; Obesity - genetics ; original-article ; Overweight ; Pedigree ; Phenotype ; Properties ; Public Health ; Quantitative Trait Loci ; Review boards ; Risk factors ; Skinfold Thickness ; Statistics as Topic ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Women</subject><ispartof>International Journal of Obesity, 2007-12, Vol.31 (12), p.1832-1842</ispartof><rights>Springer Nature Limited 2007</rights><rights>2008 INIST-CNRS</rights><rights>COPYRIGHT 2007 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Dec 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c559t-c2ee8132bd4aeb90b0deb0bf127076654b39dfe6bc235cb707d2d0bd5c3a6d03</citedby><cites>FETCH-LOGICAL-c559t-c2ee8132bd4aeb90b0deb0bf127076654b39dfe6bc235cb707d2d0bd5c3a6d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19869299$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17621312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dai, F</creatorcontrib><creatorcontrib>Keighley, E D</creatorcontrib><creatorcontrib>Sun, G</creatorcontrib><creatorcontrib>Indugula, S R</creatorcontrib><creatorcontrib>Roberts, S T</creatorcontrib><creatorcontrib>Åberg, K</creatorcontrib><creatorcontrib>Smelser, D</creatorcontrib><creatorcontrib>Tuitele, J</creatorcontrib><creatorcontrib>Jin, L</creatorcontrib><creatorcontrib>Deka, R</creatorcontrib><creatorcontrib>Weeks, D E</creatorcontrib><creatorcontrib>McGarvey, S T</creatorcontrib><title>Genome-wide scan for adiposity-related phenotypes in adults from American Samoa</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Objective:
To detect quantitative trait loci influencing adiposity-related phenotypes assessed by body mass index (BMI), abdominal circumference (ABDCIR), percent body fat (%BFAT) and fasting serum leptin and adiponectin using a whole genome linkage scan of families from American Samoa.
Design:
Family-based linkage analysis, the probands and family members were unselected for obesity.
Subjects:
A total of 583 phenotyped American Samoan adults, of which 578 were genotyped in 34 pedigrees.
Measurements:
A total of 377 autosomal and 18 X chromosome microsatellite markers were typed at an approximate average spacing of 10 c
M
spanning the genome. Multipoint LOD (logarithm of the odds) scores were calculated using variance-components approaches and SOLAR/LOKI software. The covariates simultaneously evaluated were age, sex, education, farm work and cigarette smoking, with a significance level of 0.1. Due to the stochastic nature of LOKI, we report the average of maximum LOD scores from 10 runs.
Results:
Significant linkage to leptin was found at 6q32.2 with LOD of 3.83. Suggestive linkage to leptin was found at 16q21:LOD=2.98, 1q42.2:LOD=1.97, 5q11.2:LOD=2.08, 12q24.23:LOD=2.00, 19p13.3:LOD=2.05; adiponectin was linked to 13q33.1–q22.1:LOD=2.41; %BFAT was linked to 16q12.2–q21, LOD=2.24; ABDCIR was linked to 16q23.1:LOD=1.95; %BFAT-adjusted leptin to 14q12, LOD=2.01; %BFAT-adjusted ABDCIR to 1q31.1, LOD=2.36, to 3q27.3–q28, LOD=2.10 and to 12p12.3, LOD=2.04.
Conclusion:
We found strong evidence for a major locus on 6q23.2 influencing serum leptin levels in American Samoans. The 16q21 region appears to harbor a susceptibility locus that has significant pleiotrophic effects on phenotypes BMI, %BFAT, leptin and ABDCIR as shown by bivariate linkage analyses. Several other loci of varying significance were detected across the genome.</description><subject>Adipose tissues</subject><subject>Adiposity - ethnology</subject><subject>Adiposity - genetics</subject><subject>Adult</subject><subject>Adults</subject><subject>American Samoa</subject><subject>Biological and medical sciences</subject><subject>Body fat</subject><subject>Body Mass Index</subject><subject>Chromosome Mapping</subject><subject>Cigarettes</subject><subject>Diabetes</subject><subject>Education</subject><subject>Epidemiology</subject><subject>Families & family life</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene mapping</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic Linkage - genetics</subject><subject>Genome, Human</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Health aspects</subject><subject>Health Promotion and Disease Prevention</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Leptin</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Modernization</subject><subject>Obesity</subject><subject>Obesity - ethnology</subject><subject>Obesity - genetics</subject><subject>original-article</subject><subject>Overweight</subject><subject>Pedigree</subject><subject>Phenotype</subject><subject>Properties</subject><subject>Public Health</subject><subject>Quantitative Trait Loci</subject><subject>Review boards</subject><subject>Risk factors</subject><subject>Skinfold Thickness</subject><subject>Statistics as Topic</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Women</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFksGL1DAUxoso7rh69ShFcW-dfUmatDkOi67Cwh7ce0iT152UtqlJyzL_vRmmMCorkkPgvd_3PV7yZdl7AlsCrL6O3dZ1fgs1MFHxF9mGlJUoeCmrl9kGGFQFcMEvsjcxdgDAOdDX2QWpBCWM0E12f4ujH7B4chbzaPSYtz7k2rrJRzcfioC9ntHm0z5x82HCmLsx9Zd-jnkb_JDvBgzuKPyhB6_fZq9a3Ud8t96X2cPXLw8334q7-9vvN7u7wnAu58JQxJow2thSYyOhAYsNNC2hFVRC8LJh0rYoGkMZN00qWmqhsdwwLSywy-zqZDsF_3PBOKvBRYN9r0f0S1Si5iVjRPwXpAAEiKAJ_PgX2PkljGkHRYmkwKHiCfp0gh51j8qNrZ-DNkdHtSMSCCcMjtT2GSodi4MzfsTWpfofgqvfBHvU_byPvl9m58f4rLMJPsaArZqCG3Q4KALqmAcVO5XyoNY8JMGHdaulGdCe8TUACfi8Ajr9ft8GPRoXz5yshaRSJu76xMXUGh8xnJ_nH6N_AWg9y40</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>Dai, F</creator><creator>Keighley, E D</creator><creator>Sun, G</creator><creator>Indugula, S R</creator><creator>Roberts, S T</creator><creator>Åberg, K</creator><creator>Smelser, D</creator><creator>Tuitele, J</creator><creator>Jin, L</creator><creator>Deka, R</creator><creator>Weeks, D E</creator><creator>McGarvey, S T</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20071201</creationdate><title>Genome-wide scan for adiposity-related phenotypes in adults from American Samoa</title><author>Dai, F ; Keighley, E D ; Sun, G ; Indugula, S R ; Roberts, S T ; Åberg, K ; Smelser, D ; Tuitele, J ; Jin, L ; Deka, R ; Weeks, D E ; McGarvey, S T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c559t-c2ee8132bd4aeb90b0deb0bf127076654b39dfe6bc235cb707d2d0bd5c3a6d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adipose tissues</topic><topic>Adiposity - ethnology</topic><topic>Adiposity - genetics</topic><topic>Adult</topic><topic>Adults</topic><topic>American Samoa</topic><topic>Biological and medical sciences</topic><topic>Body fat</topic><topic>Body Mass Index</topic><topic>Chromosome Mapping</topic><topic>Cigarettes</topic><topic>Diabetes</topic><topic>Education</topic><topic>Epidemiology</topic><topic>Families & family life</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene mapping</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic Linkage - genetics</topic><topic>Genome, Human</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Health aspects</topic><topic>Health Promotion and Disease Prevention</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Leptin</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Modernization</topic><topic>Obesity</topic><topic>Obesity - ethnology</topic><topic>Obesity - genetics</topic><topic>original-article</topic><topic>Overweight</topic><topic>Pedigree</topic><topic>Phenotype</topic><topic>Properties</topic><topic>Public Health</topic><topic>Quantitative Trait Loci</topic><topic>Review boards</topic><topic>Risk factors</topic><topic>Skinfold Thickness</topic><topic>Statistics as Topic</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dai, F</creatorcontrib><creatorcontrib>Keighley, E D</creatorcontrib><creatorcontrib>Sun, G</creatorcontrib><creatorcontrib>Indugula, S R</creatorcontrib><creatorcontrib>Roberts, S T</creatorcontrib><creatorcontrib>Åberg, K</creatorcontrib><creatorcontrib>Smelser, D</creatorcontrib><creatorcontrib>Tuitele, J</creatorcontrib><creatorcontrib>Jin, L</creatorcontrib><creatorcontrib>Deka, R</creatorcontrib><creatorcontrib>Weeks, D E</creatorcontrib><creatorcontrib>McGarvey, S T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dai, F</au><au>Keighley, E D</au><au>Sun, G</au><au>Indugula, S R</au><au>Roberts, S T</au><au>Åberg, K</au><au>Smelser, D</au><au>Tuitele, J</au><au>Jin, L</au><au>Deka, R</au><au>Weeks, D E</au><au>McGarvey, S T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genome-wide scan for adiposity-related phenotypes in adults from American Samoa</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>31</volume><issue>12</issue><spage>1832</spage><epage>1842</epage><pages>1832-1842</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>Objective:
To detect quantitative trait loci influencing adiposity-related phenotypes assessed by body mass index (BMI), abdominal circumference (ABDCIR), percent body fat (%BFAT) and fasting serum leptin and adiponectin using a whole genome linkage scan of families from American Samoa.
Design:
Family-based linkage analysis, the probands and family members were unselected for obesity.
Subjects:
A total of 583 phenotyped American Samoan adults, of which 578 were genotyped in 34 pedigrees.
Measurements:
A total of 377 autosomal and 18 X chromosome microsatellite markers were typed at an approximate average spacing of 10 c
M
spanning the genome. Multipoint LOD (logarithm of the odds) scores were calculated using variance-components approaches and SOLAR/LOKI software. The covariates simultaneously evaluated were age, sex, education, farm work and cigarette smoking, with a significance level of 0.1. Due to the stochastic nature of LOKI, we report the average of maximum LOD scores from 10 runs.
Results:
Significant linkage to leptin was found at 6q32.2 with LOD of 3.83. Suggestive linkage to leptin was found at 16q21:LOD=2.98, 1q42.2:LOD=1.97, 5q11.2:LOD=2.08, 12q24.23:LOD=2.00, 19p13.3:LOD=2.05; adiponectin was linked to 13q33.1–q22.1:LOD=2.41; %BFAT was linked to 16q12.2–q21, LOD=2.24; ABDCIR was linked to 16q23.1:LOD=1.95; %BFAT-adjusted leptin to 14q12, LOD=2.01; %BFAT-adjusted ABDCIR to 1q31.1, LOD=2.36, to 3q27.3–q28, LOD=2.10 and to 12p12.3, LOD=2.04.
Conclusion:
We found strong evidence for a major locus on 6q23.2 influencing serum leptin levels in American Samoans. The 16q21 region appears to harbor a susceptibility locus that has significant pleiotrophic effects on phenotypes BMI, %BFAT, leptin and ABDCIR as shown by bivariate linkage analyses. Several other loci of varying significance were detected across the genome.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>17621312</pmid><doi>10.1038/sj.ijo.0803675</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2007-12, Vol.31 (12), p.1832-1842 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68543316 |
| source | Nature |
| subjects | Adipose tissues Adiposity - ethnology Adiposity - genetics Adult Adults American Samoa Biological and medical sciences Body fat Body Mass Index Chromosome Mapping Cigarettes Diabetes Education Epidemiology Families & family life Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gene mapping Genes Genetic aspects Genetic Linkage - genetics Genome, Human Genomes Genomics Health aspects Health Promotion and Disease Prevention Humans Internal Medicine Leptin Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Middle Aged Modernization Obesity Obesity - ethnology Obesity - genetics original-article Overweight Pedigree Phenotype Properties Public Health Quantitative Trait Loci Review boards Risk factors Skinfold Thickness Statistics as Topic Vertebrates: anatomy and physiology, studies on body, several organs or systems Women |
| title | Genome-wide scan for adiposity-related phenotypes in adults from American Samoa |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T20%3A37%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genome-wide%20scan%20for%20adiposity-related%20phenotypes%20in%20adults%20from%20American%20Samoa&rft.jtitle=International%20Journal%20of%20Obesity&rft.au=Dai,%20F&rft.date=2007-12-01&rft.volume=31&rft.issue=12&rft.spage=1832&rft.epage=1842&rft.pages=1832-1842&rft.issn=0307-0565&rft.eissn=1476-5497&rft.coden=IJOBDP&rft_id=info:doi/10.1038/sj.ijo.0803675&rft_dat=%3Cgale_proqu%3EA190151305%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c559t-c2ee8132bd4aeb90b0deb0bf127076654b39dfe6bc235cb707d2d0bd5c3a6d03%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=219205075&rft_id=info:pmid/17621312&rft_galeid=A190151305&rfr_iscdi=true |