Histological and immunological features of non-eosinophilic nasal polyps

The aim of this study was to investigate the histoimmunological features of non-eosinophilic nasal polyps (NPs). Thirty patients with chronic rhinosinusitis and NPs were included in this study. NPs were grouped into eosinophilic and non-eosinophilic types according to the amount of eosinophils in th...

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Bibliographic Details
Published in:Otolaryngology-head and neck surgery 2007-12, Vol.137 (6), p.925-930
Main Authors: Kim, Jeong-Whun, Hong, Sung-Lyong, Kim, Yoon-Keun, Lee, Chul Hee, Min, Yang-Gi, Rhee, Chae-Seo
Format: Article
Language:English
Subjects:
Adult
Aged
Basement Membrane - pathology
Chronic Disease
Eosinophilia - blood
Eosinophilia - immunology
Eosinophils - immunology
Eosinophils - pathology
Female
Fluorescein-5-isothiocyanate
Fluorescent Dyes
Humans
Immunoglobulin E - blood
Immunohistochemistry
Leukocyte Count
Lymphocytes - immunology
Lymphocytes - pathology
Male
Middle Aged
Nasal Polyps - immunology
Nasal Polyps - pathology
Receptors, CCR3 - analysis
Receptors, CCR5 - analysis
Rhinitis - immunology
Rhinitis - pathology
Sinusitis - immunology
Sinusitis - pathology
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Summary:The aim of this study was to investigate the histoimmunological features of non-eosinophilic nasal polyps (NPs). Thirty patients with chronic rhinosinusitis and NPs were included in this study. NPs were grouped into eosinophilic and non-eosinophilic types according to the amount of eosinophils in the NPs. The amount of serum total IgE and peripheral blood eosinophils were measured. Basement membrane (BM) thickness was measured, along with the expression of chemokine receptor 5 (CCR5) and chemokine receptor 3 (CCR3) in NP lymphocytes. Non-eosinophilic NPs comprised 66.7% of the total NPs included in this study. The amount of eosinophils in NPs was related to eosinophilia of the peripheral blood, but not to elevated serum IgE. BM was significantly thinner in non-eosinophilic than in eosinophilic NPs. Lymphocytes expressing CCR5 or CCR3 were less frequently found in non-eosinophilic than in eosinophilic NPs. Histoimmunological characteristics of non-eosinophilic NPs differ from those of eosinophilic NPs; non-eosinophilic NPs may be featured by thinner BM and fewer CCR5- and CCR3-positive lymphocytes.
ISSN:0194-5998
1097-6817
DOI:10.1016/j.otohns.2007.07.036