One-year follow-up of percutaneous septal ablation for symptomatic hypertrophic obstructive cardiomyopathy in 312 patients: predictors of hemodynamic and clinical response

The aim of this study was to analyze hemodynamic and clinical outcome in a cohort of 312 patients who were followed up over a period of 12 months after alcohol septal ablation (PTSMA) for symptomatic hypertrophic obstructive cardiomyopathy (HOCM). PTSMA was intended in 337 patients with HOCM (mean a...

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Bibliographic Details
Published in:Clinical research in cardiology 2007-12, Vol.96 (12), p.864-873
Main Authors: Faber, L, Welge, D, Fassbender, D, Schmidt, H K, Horstkotte, D, Seggewiss, H
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Cardiomyopathy, Hypertrophic - diagnostic imaging
Cardiomyopathy, Hypertrophic - drug therapy
Cardiomyopathy, Hypertrophic - physiopathology
Chi-Square Distribution
Echocardiography
Ethanol - therapeutic use
Female
Follow-Up Studies
Heart Septum - drug effects
Heart Septum - physiopathology
Hemodynamics
Humans
Logistic Models
Male
Middle Aged
Solvents - therapeutic use
Survival Analysis
Treatment Outcome
Ventricular Outflow Obstruction - diagnostic imaging
Ventricular Outflow Obstruction - drug therapy
Ventricular Outflow Obstruction - physiopathology
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Summary:The aim of this study was to analyze hemodynamic and clinical outcome in a cohort of 312 patients who were followed up over a period of 12 months after alcohol septal ablation (PTSMA) for symptomatic hypertrophic obstructive cardiomyopathy (HOCM). PTSMA was intended in 337 patients with HOCM (mean age: 54+/-15 years), with 312 procedures completed by injection of 2.8+/-1.2 ml of alcohol. In 25 patients (8%) the intervention was aborted, mostly because of contrast echocardiographic findings. In the 312 patients who received alcohol, permanent pacing was necessary in 22 cases (7%); and in-hospital mortality was 1.3% (four patients). During follow-up, contact to six patients (2%) was lost, and three additional patients (1%) died. The 299 patients who either underwent non-invasive reassessment in our institution or transmitted followup data from their local physician formed the study population. Improvement in symptoms was reported by 272 patients (91%). Mean NYHA functional class was reduced from 2.9+/-0.4 to 1.5+/-0.7 (p
ISSN:1861-0684
1861-0692
DOI:10.1007/s00392-007-0578-9