Plasmablastic lymphomas may occur as post-transplant lymphoproliferative disorders

Aims:  To describe four cases of plasmablastic lymphoma arising in the unusual setting of a post‐transplantation lymphoproliferative disorder (PTLD). Methods and results:  Four cases were encountered over 2 years in human immunodeficiency virus (HIV)‐negative patients following renal, heart or bone...

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Bibliographic Details
Published in:Histopathology 2007-12, Vol.51 (6), p.774-777
Main Authors: Borenstein, J, Pezzella, F, Gatter, K C
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Bone Marrow Transplantation - adverse effects
Epstein-Barr Virus Infections
Heart Transplantation - adverse effects
Herpesvirus 4, Human
HIV
Human immunodeficiency virus
Human immunodeficiency virus 2
Humans
Immunohistochemistry
Investigative techniques, diagnostic techniques (general aspects)
Kidney Transplantation - adverse effects
lymphoma
Lymphoma, Large-Cell, Immunoblastic - etiology
Lymphoma, Large-Cell, Immunoblastic - virology
Male
Medical sciences
Middle Aged
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
plasmablastic
post-transplantation
Postoperative Complications
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Summary:Aims:  To describe four cases of plasmablastic lymphoma arising in the unusual setting of a post‐transplantation lymphoproliferative disorder (PTLD). Methods and results:  Four cases were encountered over 2 years in human immunodeficiency virus (HIV)‐negative patients following renal, heart or bone marrow transplantation. The cases were routinely processed and immunohistochemistry was performed. The cases showed blastic non‐Hodgkin’s lymphoma morphology and plasma cell‐like immunophenotypic features: minimal or absent expression of leucocyte common antigen and CD20, variable CD79a and VS38 positivity. Monoclonal light chain restriction was also detected. Conclusions:  The emphasis of this paper is to document further the occurrence of plasmablastic lymphomas in HIV− individuals and to expand the spectrum of PTLD.
ISSN:0309-0167
1365-2559
DOI:10.1111/j.1365-2559.2007.02870.x