Genetic and environmental correlations between bone phenotypes and anthropometric indices in Chinese

Height, weight, bone mineral density (BMD), and bone size are all influenced by genetic and environmental factors as well as interactions between them. Height and weight are often used in population studies to adjust the bone phenotypes. However, it is still unknown what proportion of genetic and en...

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Bibliographic Details
Published in:Osteoporosis international 2005-09, Vol.16 (9), p.1134-1140
Main Authors: YANG, Yan-Jun, DVORNYK, Volodymyr, JIAN, Wei-Xia, XIAO, Su-Mei, DENG, Hong-Wen
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Adult
Aged
Anthropometry
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Body Height - genetics
Body Weight - genetics
Bone density
Bone Density - genetics
China
Diseases of the osteoarticular system
Female
Hip Joint - physiology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lumbar Vertebrae - physiology
Male
Medical sciences
Middle Aged
Nuclear family
Osteoarticular system. Muscles
Osteoporosis
Osteoporosis. Osteomalacia. Paget disease
Phenotype
Quantitative genetics
Radiodiagnosis. Nmr imagery. Nmr spectrometry
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Summary:Height, weight, bone mineral density (BMD), and bone size are all influenced by genetic and environmental factors as well as interactions between them. Height and weight are often used in population studies to adjust the bone phenotypes. However, it is still unknown what proportion of genetic and environmental variability is shared between these anthropometric characteristics and the bone phenotypes. The genetic and environmental correlations between the bone phenotypes and anthropometric indices in Chinese subjects were studied by bivariate quantitative genetic analysis on a sample of 931 healthy subjects from 292 Chinese nuclear families aged from 19 to 79 years. BMD and bone size at the lumbar spine (L1-L4) and the hip of all subjects were measured by dual-energy X-ray absorptiometry. We found significant genetic correlations between weight and spine BMD, hip BMD, spine bone size and hip bone size, which were 0.50 (P
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-004-1825-9