Red wine reduces oxidative stress in patients with acute coronary syndrome

• Published in: International journal of cardiology 2005-09, Vol.104 (1), p.35-38
• Main Authors: Guarda, Eduardo, Godoy, Iván, Foncea, Rocío, Pérez, Druso D., Romero, Carlos, Venegas, Reinaldo, Leighton, Federico
• Format: Article
• Language: English
• Subjects: Acute coronary syndrome; Acute Disease; Antioxidants - metabolism; Biological and medical sciences; Biomarkers - blood; Blood Flow Velocity - drug effects; Brachial Artery - drug effects; Brachial Artery - metabolism; Brachial Artery - physiopathology; Cardiology. Vascular system; Cholesterol, HDL - blood; Cholesterol, HDL - drug effects; Cholesterol, LDL - blood; Cholesterol, LDL - drug effects; Coronary Disease - metabolism; Coronary Disease - physiopathology; Coronary heart disease; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - metabolism; DNA - metabolism; Endothelium, Vascular - drug effects; Endothelium, Vascular - metabolism; Endothelium, Vascular - physiopathology; Female; Heart; Humans; Leukocytes - metabolism; Male; Medical sciences; Middle Aged; Myocardial Infarction - metabolism; Oxidative Stress - drug effects; Syndrome; Vasodilation - drug effects; Wine
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/j.ijcard.2004.10.013

Moderate red wine consumption improved endothelial function in normal volunteers. Herein we explored the effects of moderate red wine consumption in endothelial function and in oxidative stress in patients with an acute coronary syndrome. 20 patients treated with percutaneous coronary interventions after an acute coronary syndrome were randomized to a red-wine group ( n=9, 250 ml daily, Cabernet Sauvignon) or to a control group ( n=11, abstinence from alcoholic beverages). Studies were performed at baseline and after 2 months. Endothelial function was estimated by flow-mediated vasodilatation of the brachial artery. Plasma antioxidant capacity was measured by total antioxidant reactivity and ferric reducing antioxidant power. Oxidative damage was evaluated by measurements of 8-OH deoxyguanosine content in leukocyte deoxyribonucleic acid. The endothelium dependent/independent dilatation ratio significantly improved compared to baseline in both groups. The 8-OH deoxyguanosine content decreased significantly in both groups; this effect was more pronounced with wine ( p