The in Vivo Effect of Cordyceps sinensis Mycelium on Plasma Corticosterone Level in Male Mouse

Cordyceps sinensis (CS), an Ascomycetes fungus parasitic to Lepidoptera larvae, has been traditionally used as nutritious food for the enhancement in immuno-modulation in Chinese society for a long time. Previous report has demonstrated the CS water extract stimulates in vitro corticosterone product...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2005, Vol.28(9), pp.1722-1725
Main Authors: Leu, Sew-Fen, Chien, Chi-Hsien, Tseng, Chi-Yu, Kuo, Yu-Ming, Huang, Bu-Miin
Format: Article
Language:English
Subjects:
adrenal gland
Adrenal Glands - drug effects
Animals
Ascomycetes
Body Weight - drug effects
Cordyceps - chemistry
Cordyceps sinensis
Cordyceps sinensis (CS)
corticosterone
Corticosterone - blood
in vivo
Lepidoptera
Male
Mice
Mice, Inbred C57BL
mouse
Mycelium - chemistry
Organ Size - drug effects
Radioimmunoassay
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Summary:Cordyceps sinensis (CS), an Ascomycetes fungus parasitic to Lepidoptera larvae, has been traditionally used as nutritious food for the enhancement in immuno-modulation in Chinese society for a long time. Previous report has demonstrated the CS water extract stimulates in vitro corticosterone production in rat primary adrenal cells. In the present studies, we determined the in vivo effects of CS and its fractions on plasma corticosterone production in mouse. Different concentrations of CS and CS fractions dissolved in water (0.02 and 0.2 mg/g body weight) were fed to immature and mature mice from 1, 3 or 7 d. The plasma levels of corticosterone were determined by radioimmunoassay (RIA), and the weight of adrenal gland and body weight were also evaluated. Results illustrated that plasma corticosterone levels were significantly induced by F2 at 0.02 mg/g body weight with 7 d feeding in immature mice, and by CS at 0.02 mg/g body weight with 3 d feeding and F3 at 0.02 mg/g body weight for 7 d feeding in mature mice, respectively (p
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.28.1722