Polymorphism of the untranslated regions of the F3/contactin mRNA in the rat nervous system

F3/contactin is a neural adhesion molecule implicated in various physiological processes. In rat brain tissues, we cloned various mRNA with the same coding region but differing in 3′ and 5′UTR. The 3′UTR presents two polyadenylation signals. At the 5′ end, we identified two leader exons, multiple tr...

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Bibliographic Details
Published in:Brain research. Molecular brain research. 2005-09, Vol.139 (1), p.184-191
Main Authors: Rome, Claire, Roullot, Valérie, Couillaud, Franck
Format: Article
Language:English
Subjects:
Alternative Splicing
Animals
Base Sequence
Biological and medical sciences
Brain
Brain - physiology
Cell Adhesion Molecules, Neuronal - genetics
Contactins
Exons
F3/contactin
Fundamental and applied biological sciences. Psychology
Mice
Molecular Sequence Data
Polymorphism, Genetic
Rats
RNA, Messenger - metabolism
Sequence Alignment
Transcription Initiation Site
Untranslated Regions - genetics
UTR
Vertebrates: nervous system and sense organs
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Summary:F3/contactin is a neural adhesion molecule implicated in various physiological processes. In rat brain tissues, we cloned various mRNA with the same coding region but differing in 3′ and 5′UTR. The 3′UTR presents two polyadenylation signals. At the 5′ end, we identified two leader exons, multiple transcription initiation sites and splicing events, leading to at least 19 different 5′UTR. The F3/ contactin rat gene differs from the mouse gene for two reasons: (1) it contains two additional untranslated exons that are alternatively spliced and (2) it lacks the homologue mouse untranslated exon 0.
ISSN:0169-328X
1872-6941
DOI:10.1016/j.molbrainres.2005.05.012