RNA Structure: Reading the Ribosome

The crystal structures of the ribosome and its subunits have increased the amount of information about RNA structure by about two orders of magnitude. This is leading to an understanding of the principles of RNA folding and of the molecular interactions that underlie the functional capabilities of t...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2005-09, Vol.309 (5740), p.1508-1514
Main Author: Noller, Harry F
Format: Article
Language:English
Subjects:
Biochemistry
Crystal structure
Crystallography, X-Ray
Literary Devices
Messenger RNA
Models, Molecular
Molecular structure
Nucleic Acid Conformation
Nucleic acids
Nucleotides
Phosphates
Protein folding
Reviews
Ribonucleic acid
Ribosomal proteins
Ribosomes
Ribosomes - chemistry
RNA
RNA - chemistry
RNA, Ribosomal - chemistry
RNA, Transfer - chemistry
Spectroscopy
Structural Analysis (Linguistics)
Structural Analysis (Science)
Structure
Transfer RNA
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Summary:The crystal structures of the ribosome and its subunits have increased the amount of information about RNA structure by about two orders of magnitude. This is leading to an understanding of the principles of RNA folding and of the molecular interactions that underlie the functional capabilities of the ribosome and other RNA systems. Nearly all of the possible types of RNA tertiary interactions have been found in ribosomal RNA. One of these, an abundant tertiary structural motif called the A-minor interaction, has been shown to participate in both aminoacyl-transfer RNA selection and in peptidyl transferase; it may also play an important role in the structural dynamics of the ribosome.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1111771