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Inhibitory effects of desflurane and sevoflurane on oxytocin-induced contractions of isolated pregnant human myometrium
Background: In this study, we investigated the inhibitory effects of desflurane and sevoflurane on oxytocin‐induced contractions of isolated human myometrium. Methods: Following delivery of the infant and placenta, a small segment of myometrium was excised from the upper incisional surface of the...
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| Published in: | Acta anaesthesiologica Scandinavica 2005-10, Vol.49 (9), p.1355-1359 |
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| container_title | Acta anaesthesiologica Scandinavica |
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| creator | Yildiz, K. Dogru, K. Dalgic, H. Serin, I. S. Sezer, Z. Madenoglu, H. Boyacı, A. |
| description | Background: In this study, we investigated the inhibitory effects of desflurane and sevoflurane on oxytocin‐induced contractions of isolated human myometrium.
Methods: Following delivery of the infant and placenta, a small segment of myometrium was excised from the upper incisional surface of the lower uterine segment and 20 strips, randomly assigned into two groups (n = 10), were obtained from 20 non‐laboring term parturients. The study protocol consisted of a 60‐min period of spontaneous contractions, control recording with oxytocin 2 × 109 m (10‐min period), washout interval of 10 min, volatile administration (three times per 15‐min period) of 0.5, 1 and 2 minimum alveolar concentration (MAC), response to oxytocin (10‐min period), a further washout interval (10‐min period) and subsequent control recording with oxytocin without anesthetics.
Results: After oxytocin administration, the frequency and amplitude of contractions increased (P |
| doi_str_mv | 10.1111/j.1399-6576.2005.00804.x |
| format | article |
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Methods: Following delivery of the infant and placenta, a small segment of myometrium was excised from the upper incisional surface of the lower uterine segment and 20 strips, randomly assigned into two groups (n = 10), were obtained from 20 non‐laboring term parturients. The study protocol consisted of a 60‐min period of spontaneous contractions, control recording with oxytocin 2 × 109 m (10‐min period), washout interval of 10 min, volatile administration (three times per 15‐min period) of 0.5, 1 and 2 minimum alveolar concentration (MAC), response to oxytocin (10‐min period), a further washout interval (10‐min period) and subsequent control recording with oxytocin without anesthetics.
Results: After oxytocin administration, the frequency and amplitude of contractions increased (P < 0.05) and the duration decreased (P < 0.05). The frequency and amplitude of contractions induced with oxytocin decreased significantly at 0.5, 1 and 2 MAC of desflurane and sevoflurane (P < 0.05). The amplitude of contractions was significantly different at 1 MAC between the two groups (P < 0.05). The duration of contractions at 2 MAC decreased in both groups (P < 0.05).
Conclusions: Desflurane and sevoflurane at 0.5, 1 and 2 MAC inhibit the frequency and amplitude of myometrial contractions induced with oxytocin in a dose‐dependent manner. However, desflurane inhibits the amplitude less than sevoflurane at 1 MAC. We suggest that 0.5 MAC of both agents and 1 MAC of desflurane may be safely used in the presence of oxytocin following delivery of the infant and placenta during Cesarean section without fear of uterine atony and hemorrhage.</description><identifier>ISSN: 0001-5172</identifier><identifier>EISSN: 1399-6576</identifier><identifier>DOI: 10.1111/j.1399-6576.2005.00804.x</identifier><identifier>PMID: 16146475</identifier><identifier>CODEN: AANEAB</identifier><language>eng</language><publisher>Oxford, UK; Malden, USA: Blackwell Publishing Ltd/Inc</publisher><subject>Adult ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anesthetics, Inhalation - pharmacology ; Biological and medical sciences ; Desflurane ; Female ; gravid ; Humans ; In Vitro Techniques ; Isoflurane - analogs & derivatives ; Isoflurane - pharmacology ; isolated ; Medical sciences ; Methyl Ethers - pharmacology ; minimum alveolar concentration ; myometrium ; Myometrium - drug effects ; oxytocin ; Oxytocin - pharmacology ; Pregnancy ; sevoflurane ; Uterine Contraction - drug effects</subject><ispartof>Acta anaesthesiologica Scandinavica, 2005-10, Vol.49 (9), p.1355-1359</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5004-a9b3f363e621ea8c2334c127e34c9bc27387fd67e0f6f071cd70a92e52eca0683</citedby><cites>FETCH-LOGICAL-c5004-a9b3f363e621ea8c2334c127e34c9bc27387fd67e0f6f071cd70a92e52eca0683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17087872$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16146475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yildiz, K.</creatorcontrib><creatorcontrib>Dogru, K.</creatorcontrib><creatorcontrib>Dalgic, H.</creatorcontrib><creatorcontrib>Serin, I. S.</creatorcontrib><creatorcontrib>Sezer, Z.</creatorcontrib><creatorcontrib>Madenoglu, H.</creatorcontrib><creatorcontrib>Boyacı, A.</creatorcontrib><title>Inhibitory effects of desflurane and sevoflurane on oxytocin-induced contractions of isolated pregnant human myometrium</title><title>Acta anaesthesiologica Scandinavica</title><addtitle>Acta Anaesthesiol Scand</addtitle><description>Background: In this study, we investigated the inhibitory effects of desflurane and sevoflurane on oxytocin‐induced contractions of isolated human myometrium.
Methods: Following delivery of the infant and placenta, a small segment of myometrium was excised from the upper incisional surface of the lower uterine segment and 20 strips, randomly assigned into two groups (n = 10), were obtained from 20 non‐laboring term parturients. The study protocol consisted of a 60‐min period of spontaneous contractions, control recording with oxytocin 2 × 109 m (10‐min period), washout interval of 10 min, volatile administration (three times per 15‐min period) of 0.5, 1 and 2 minimum alveolar concentration (MAC), response to oxytocin (10‐min period), a further washout interval (10‐min period) and subsequent control recording with oxytocin without anesthetics.
Results: After oxytocin administration, the frequency and amplitude of contractions increased (P < 0.05) and the duration decreased (P < 0.05). The frequency and amplitude of contractions induced with oxytocin decreased significantly at 0.5, 1 and 2 MAC of desflurane and sevoflurane (P < 0.05). The amplitude of contractions was significantly different at 1 MAC between the two groups (P < 0.05). The duration of contractions at 2 MAC decreased in both groups (P < 0.05).
Conclusions: Desflurane and sevoflurane at 0.5, 1 and 2 MAC inhibit the frequency and amplitude of myometrial contractions induced with oxytocin in a dose‐dependent manner. However, desflurane inhibits the amplitude less than sevoflurane at 1 MAC. We suggest that 0.5 MAC of both agents and 1 MAC of desflurane may be safely used in the presence of oxytocin following delivery of the infant and placenta during Cesarean section without fear of uterine atony and hemorrhage.</description><subject>Adult</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anesthetics, Inhalation - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Desflurane</subject><subject>Female</subject><subject>gravid</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Isoflurane - analogs & derivatives</subject><subject>Isoflurane - pharmacology</subject><subject>isolated</subject><subject>Medical sciences</subject><subject>Methyl Ethers - pharmacology</subject><subject>minimum alveolar concentration</subject><subject>myometrium</subject><subject>Myometrium - drug effects</subject><subject>oxytocin</subject><subject>Oxytocin - pharmacology</subject><subject>Pregnancy</subject><subject>sevoflurane</subject><subject>Uterine Contraction - drug effects</subject><issn>0001-5172</issn><issn>1399-6576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNkE9vFCEYh4nR2G31KxguepsRhgFmEi-bRmtjowc17Y2wzItlnYEVGLv77ct21_Yql5c37_Pjz4MQpqSmZb1f15T1fSW4FHVDCK8J6Uhbb5-hxePgOVoQQmjFqWxO0GlK69Kytu9fohMqaCtayRfo7tLfupXLIe4wWAsmJxwsHiDZcY7aA9Z-wAn-hn998DhsdzkY5yvnh9nAgE3wOWqTXfAPcZfCqHMZbCL88tpnfDtP2uNpFybI0c3TK_TC6jHB62M9Qz8_ffxx_rm6-nZxeb68qgwnpK10v2KWCQaioaA70zDWGtpIKKVfmUayTtpBSCBWWCKpGSTRfQO8AaOJ6NgZenc4dxPDnxlSVpNLBsaxfCXMSYmOc1FUFLA7gCaGlCJYtYlu0nGnKFF76Wqt9m7V3q3aS1cP0tW2RN8c75hXEwxPwaPlArw9AjoZPdri0bj0xEnSyU42hftw4O7cCLv_foBaLr-XTYlXh7hLGbaPcR1_KyGZ5Or664Wi1zf0C-u4umH3CXKu7A</recordid><startdate>200510</startdate><enddate>200510</enddate><creator>Yildiz, K.</creator><creator>Dogru, K.</creator><creator>Dalgic, H.</creator><creator>Serin, I. S.</creator><creator>Sezer, Z.</creator><creator>Madenoglu, H.</creator><creator>Boyacı, A.</creator><general>Blackwell Publishing Ltd/Inc</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200510</creationdate><title>Inhibitory effects of desflurane and sevoflurane on oxytocin-induced contractions of isolated pregnant human myometrium</title><author>Yildiz, K. ; Dogru, K. ; Dalgic, H. ; Serin, I. S. ; Sezer, Z. ; Madenoglu, H. ; Boyacı, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5004-a9b3f363e621ea8c2334c127e34c9bc27387fd67e0f6f071cd70a92e52eca0683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anesthetics, Inhalation - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Desflurane</topic><topic>Female</topic><topic>gravid</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Isoflurane - analogs & derivatives</topic><topic>Isoflurane - pharmacology</topic><topic>isolated</topic><topic>Medical sciences</topic><topic>Methyl Ethers - pharmacology</topic><topic>minimum alveolar concentration</topic><topic>myometrium</topic><topic>Myometrium - drug effects</topic><topic>oxytocin</topic><topic>Oxytocin - pharmacology</topic><topic>Pregnancy</topic><topic>sevoflurane</topic><topic>Uterine Contraction - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yildiz, K.</creatorcontrib><creatorcontrib>Dogru, K.</creatorcontrib><creatorcontrib>Dalgic, H.</creatorcontrib><creatorcontrib>Serin, I. S.</creatorcontrib><creatorcontrib>Sezer, Z.</creatorcontrib><creatorcontrib>Madenoglu, H.</creatorcontrib><creatorcontrib>Boyacı, A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta anaesthesiologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yildiz, K.</au><au>Dogru, K.</au><au>Dalgic, H.</au><au>Serin, I. S.</au><au>Sezer, Z.</au><au>Madenoglu, H.</au><au>Boyacı, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory effects of desflurane and sevoflurane on oxytocin-induced contractions of isolated pregnant human myometrium</atitle><jtitle>Acta anaesthesiologica Scandinavica</jtitle><addtitle>Acta Anaesthesiol Scand</addtitle><date>2005-10</date><risdate>2005</risdate><volume>49</volume><issue>9</issue><spage>1355</spage><epage>1359</epage><pages>1355-1359</pages><issn>0001-5172</issn><eissn>1399-6576</eissn><coden>AANEAB</coden><abstract>Background: In this study, we investigated the inhibitory effects of desflurane and sevoflurane on oxytocin‐induced contractions of isolated human myometrium.
Methods: Following delivery of the infant and placenta, a small segment of myometrium was excised from the upper incisional surface of the lower uterine segment and 20 strips, randomly assigned into two groups (n = 10), were obtained from 20 non‐laboring term parturients. The study protocol consisted of a 60‐min period of spontaneous contractions, control recording with oxytocin 2 × 109 m (10‐min period), washout interval of 10 min, volatile administration (three times per 15‐min period) of 0.5, 1 and 2 minimum alveolar concentration (MAC), response to oxytocin (10‐min period), a further washout interval (10‐min period) and subsequent control recording with oxytocin without anesthetics.
Results: After oxytocin administration, the frequency and amplitude of contractions increased (P < 0.05) and the duration decreased (P < 0.05). The frequency and amplitude of contractions induced with oxytocin decreased significantly at 0.5, 1 and 2 MAC of desflurane and sevoflurane (P < 0.05). The amplitude of contractions was significantly different at 1 MAC between the two groups (P < 0.05). The duration of contractions at 2 MAC decreased in both groups (P < 0.05).
Conclusions: Desflurane and sevoflurane at 0.5, 1 and 2 MAC inhibit the frequency and amplitude of myometrial contractions induced with oxytocin in a dose‐dependent manner. However, desflurane inhibits the amplitude less than sevoflurane at 1 MAC. We suggest that 0.5 MAC of both agents and 1 MAC of desflurane may be safely used in the presence of oxytocin following delivery of the infant and placenta during Cesarean section without fear of uterine atony and hemorrhage.</abstract><cop>Oxford, UK; Malden, USA</cop><pub>Blackwell Publishing Ltd/Inc</pub><pmid>16146475</pmid><doi>10.1111/j.1399-6576.2005.00804.x</doi><tpages>5</tpages></addata></record> |
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| ispartof | Acta anaesthesiologica Scandinavica, 2005-10, Vol.49 (9), p.1355-1359 |
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| subjects | Adult Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Inhalation - pharmacology Biological and medical sciences Desflurane Female gravid Humans In Vitro Techniques Isoflurane - analogs & derivatives Isoflurane - pharmacology isolated Medical sciences Methyl Ethers - pharmacology minimum alveolar concentration myometrium Myometrium - drug effects oxytocin Oxytocin - pharmacology Pregnancy sevoflurane Uterine Contraction - drug effects |
| title | Inhibitory effects of desflurane and sevoflurane on oxytocin-induced contractions of isolated pregnant human myometrium |
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