Mechanisms of formation and disintegration of alginate beads obtained by prilling

In this paper, compendial sodium alginate beads have been manufactured by laminar jet break-up technology. The effect of polymer concentration, viscosity and polymeric solution flow rate on the characteristics of beads was studied. Size distribution of alginate beads in the hydrated state was strong...

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Bibliographic Details
Published in:International journal of pharmaceutics 2005-09, Vol.302 (1), p.1-9
Main Authors: Del Gaudio, Pasquale, Colombo, Paolo, Colombo, Gaia, Russo, Paola, Sonvico, Fabio
Format: Article
Language:English
Subjects:
Alginate beads
Alginates - chemical synthesis
Alginates - chemistry
Alginates - pharmacokinetics
Algorithms
Animals
Biological and medical sciences
Controlled drug release
Gastric Juice - metabolism
General pharmacology
Glucuronic Acid - chemical synthesis
Glucuronic Acid - chemistry
Glucuronic Acid - pharmacokinetics
Hexuronic Acids - chemical synthesis
Hexuronic Acids - chemistry
Hexuronic Acids - pharmacokinetics
Humans
Hydrogen-Ion Concentration
Intestinal Secretions - metabolism
Kinetics
Laminar jet break-up
Medical sciences
Microspheres
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Prilling
Technology, Pharmaceutical - methods
Viscosity
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Summary:In this paper, compendial sodium alginate beads have been manufactured by laminar jet break-up technology. The effect of polymer concentration, viscosity and polymeric solution flow rate on the characteristics of beads was studied. Size distribution of alginate beads in the hydrated state was strongly dependent on the flow rate and viscosity of polymer solutions, since a transition from laminar jet break-up conditions to vibration-assisted dripping was observed. The re-hydration kinetics of dried beads in simulated gastric fluid (SGF) showed that the maximum swelling of beads was reached after 1–2 h, with an increase in volume of two to three times and a time lag dependent on the polymer concentration. The re-hydration swelling profiles in simulated intestinal fluid (SIF) showed no time lag and higher swelling volume; moreover, in this medium after the maximum swelling was reached, the bead structure was quickly disaggregated because of the presence in the medium of phosphate able to capture calcium ions present in the alginate gel structure.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2005.05.041